Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor

Zhongyong Wang, Sicong Zhang, Timothy L. Siu, Suyun Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition (EMT), invasion, angiogenesis and upregulating Wnt/β-catenin signalling. Our recent experimental findings are also summarized to prove that FoxM1 is a novel therapeutic target against GBM.

Original languageEnglish
Pages (from-to)1268-1271
Number of pages4
JournalCurrent Pharmaceutical Design
Volume21
Issue number10
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Glioblastoma
  • tumorigenesis
  • EMT
  • invasion
  • angiogenesis
  • FoxM1
  • Wnt/β-catenin signaling

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