Glioblastoma presenting as spontaneous intracranial haemorrhage: case report and review of the literature

Danica M. Joseph; Anthea H. O'Neill; Ronil V. Chandra; Leon T. Lai

doi:10.1016/j.jocn.2016.12.046

Glioblastoma presenting as spontaneous intracranial haemorrhage: case report and review of the literature

Danica M. Joseph, Anthea H. O'Neill, Ronil V. Chandra, Leon T. Lai

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Glioblastoma (GB) classically presents with symptoms of raised intracranial pressure and gradual progressive neurological deficits. An acute presentation, with intracerebral haemorrhage (ICH) and rapid clinical deterioration, occurs infrequently. Contemporary imaging modalities do not reliably reflect underlying mass lesions in parenchymal brain haemorrhage at first presentation. We report a delayed diagnosis of GB in a 21-year-old patient presenting with spontaneous ICH and a negative initial neurovascular workup. A comprehensive literature review was performed to investigate the incidence of malignant aetiology for spontaneous ICH in young adults, and to underscore the importance of early utilisation of diagnostic magnetic resonance imaging (MRI) in such cases.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Journal of Clinical Neuroscience
Volume	40
Early online date	15 Feb 2017
DOIs	https://doi.org/10.1016/j.jocn.2016.12.046
Publication status	Published - Jun 2017
Externally published	Yes

Keywords

Glioblastoma
Intracerebral haemorrhage
Magnetic resonance imaging
Young adult

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10.1016/j.jocn.2016.12.046

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abstract = "Glioblastoma (GB) classically presents with symptoms of raised intracranial pressure and gradual progressive neurological deficits. An acute presentation, with intracerebral haemorrhage (ICH) and rapid clinical deterioration, occurs infrequently. Contemporary imaging modalities do not reliably reflect underlying mass lesions in parenchymal brain haemorrhage at first presentation. We report a delayed diagnosis of GB in a 21-year-old patient presenting with spontaneous ICH and a negative initial neurovascular workup. A comprehensive literature review was performed to investigate the incidence of malignant aetiology for spontaneous ICH in young adults, and to underscore the importance of early utilisation of diagnostic magnetic resonance imaging (MRI) in such cases.",

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AU - Lai, Leon T.

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AB - Glioblastoma (GB) classically presents with symptoms of raised intracranial pressure and gradual progressive neurological deficits. An acute presentation, with intracerebral haemorrhage (ICH) and rapid clinical deterioration, occurs infrequently. Contemporary imaging modalities do not reliably reflect underlying mass lesions in parenchymal brain haemorrhage at first presentation. We report a delayed diagnosis of GB in a 21-year-old patient presenting with spontaneous ICH and a negative initial neurovascular workup. A comprehensive literature review was performed to investigate the incidence of malignant aetiology for spontaneous ICH in young adults, and to underscore the importance of early utilisation of diagnostic magnetic resonance imaging (MRI) in such cases.

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Glioblastoma presenting as spontaneous intracranial haemorrhage: case report and review of the literature

Abstract

Keywords

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