Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020

Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators

doi:10.1038/s41433-024-02995-5

Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020

Vision Loss Expert Group of the Global Burden of Disease Study, the GBD 2019 Blindness and Vision Impairment Collaborators

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

9 Downloads (Pure)

Abstract

Objectives: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. Methods: A systematic review and meta-analysis of published population studies and grey literature from 2000 to 2020 was carried out to estimate global and regional trends in number of people with vision loss due to glaucoma. Moderate or severe vision loss (MSVI) was defined as visual acuity of 6/60 or better but <6/18 (moderate) and visual acuity of 3/60 or better but <6/60 (severe vision loss). Blindness was defined as presenting visual acuity <3/60. Results: Globally, in 2020, 3.61 million people were blind and nearly 4.14 million were visually impaired by glaucoma. Glaucoma accounted for 8.39% (95% uncertainty intervals [UIs]: 6.54, 10.29) of all blindness and 1.41% (95% UI: 1.10, 1.75) of all MSVI. Regionally, the highest proportion of blindness relating to glaucoma was found in high-income countries (26.12% [95% UI: 20.72, 32.09]), while the region with the highest age-standardized prevalence of glaucoma-related blindness and MSVI was Sub-Saharan Africa. Between 2000 and 2020, global age-standardized prevalence of glaucoma-related blindness among adults ≥50 years decreased by 26.06% among males (95% UI: 25.87, 26.24), and by 21.75% among females (95% UI: 21.54, 21.96), while MSVI due to glaucoma increased by 3.7% among males (95% UI: 3.42, 3.98), and by 7.3% in females (95% UI: 7.01, 7.59). Conclusions: Within the last two decades, glaucoma has remained a major cause of blindness globally and regionally.

Original language	English
Pages (from-to)	2036-2046
Number of pages	11
Journal	Eye (Basingstoke)
Volume	38
Issue number	11
Early online date	2 Apr 2024
DOIs	https://doi.org/10.1038/s41433-024-02995-5
Publication status	Published - Aug 2024

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Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1038/s41433-024-02995-5Licence: CC BY

Publisher version (open access)Final published version, 616 KBLicence: CC BY

Cite this

@article{67177712e11047dc8179876934281093,

title = "Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020",

abstract = "Objectives: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. Methods: A systematic review and meta-analysis of published population studies and grey literature from 2000 to 2020 was carried out to estimate global and regional trends in number of people with vision loss due to glaucoma. Moderate or severe vision loss (MSVI) was defined as visual acuity of 6/60 or better but <6/18 (moderate) and visual acuity of 3/60 or better but <6/60 (severe vision loss). Blindness was defined as presenting visual acuity <3/60. Results: Globally, in 2020, 3.61 million people were blind and nearly 4.14 million were visually impaired by glaucoma. Glaucoma accounted for 8.39% (95% uncertainty intervals [UIs]: 6.54, 10.29) of all blindness and 1.41% (95% UI: 1.10, 1.75) of all MSVI. Regionally, the highest proportion of blindness relating to glaucoma was found in high-income countries (26.12% [95% UI: 20.72, 32.09]), while the region with the highest age-standardized prevalence of glaucoma-related blindness and MSVI was Sub-Saharan Africa. Between 2000 and 2020, global age-standardized prevalence of glaucoma-related blindness among adults ≥50 years decreased by 26.06% among males (95% UI: 25.87, 26.24), and by 21.75% among females (95% UI: 21.54, 21.96), while MSVI due to glaucoma increased by 3.7% among males (95% UI: 3.42, 3.98), and by 7.3% in females (95% UI: 7.01, 7.59). Conclusions: Within the last two decades, glaucoma has remained a major cause of blindness globally and regionally.",

author = "{Vision Loss Expert Group of the Global Burden of Disease Study} and Bourne, {Rupert R. A.} and Jonas, {Jost B.} and David Friedman and Vinay Nangia and Bron, {Alain M.} and Ian Tapply and Fernandes, {Arthur G.} and Cicinelli, {Maria Vittoria} and Alessandro Arrigo and Nicolas Leveziel and Serge Resnikoff and Taylor, {Hugh R.} and Tabassom Sedighi and Bikbov, {Mukkharram M.} and Tasanee Braithwaite and Ching-Yu Cheng and Nathan Congdon and {Del Monte}, {Monte A.} and Ehrlich, {Joshua R.} and Tim Fricke and Furtado, {Jo{\~a}o M.} and Gus Gazzard and Ronnie George and Hartnett, {M. Elizabeth} and Rim Kahloun and Kempen, {John H.} and Moncef Khairallah and Khanna, {Rohit C.} and Kim, {Judy E.} and Lansingh, {Van Charles} and Leasher, {Janet L.} and Naidoo, {Kovin S.} and Michal Nowak and Konrad Pesudovs and Tunde Peto and Pradeep Ramulu and Fotis Topouzis and Mitiadis Tsilimbaris and Wang, {Ya Xing} and Ningli Wang and Seth Flaxman and {the GBD 2019 Blindness and Vision Impairment Collaborators} and Casson, {Robert James} and Briant, {Paul Svitil} and Theo Vos and Abate, {Yohannes Habtegiorgis} and Abate, {Melsew Dagne} and Dolatabadi, {Zahra Abbasi} and Mozhan Abdollahi and Aboagye, {Richard Gyan} and Eman Abu-Gharbieh and Salahdein Aburuz and Adnani, {Qorinah Estiningtyas Sakilah} and Shahin Aghamiri and Ahinkorah, {Bright Opoku} and Danish Ahmad and Hamid Ahmadieh and Hooman Ahmadzadeh and Ayman Ahmed and Alfaar, {Ahmad Samir} and Cyrus Alinia and Louay Almidani and Hubert Amu and Sofia Androudi and Abhishek Anil and Jalal Arabloo and Damelash Areda and Tahira Ashraf and Sara Bagherieh and Baltatu, {Ovidiu Constantin} and Baran, {Mehmet Firat} and Amadou Barrow and Azadeh Bashiri and Bayileyegn, {Nebiyou Simegnew} and Fatemeh Bazvand and Berhie, {Alemshet Yirga} and Bhatti, {Jasvinder Singh} and Birck, {Marina G.} and Bitra, {Veera R.} and Bozic, {Marija M.} and Katrin Burkart and Yasser Bustanji and Butt, {Zahid A.} and Muthia Cenderadewi and Chattu, {Vijay Kumar} and Kaleb Coberly and Omid Dadras and Xiaochen Dai and Dascalu, {Ana Maria} and Anna Dastiridou and Devanbu, {Vinoth Gnana Chellaiyan} and Meghnath Dhimal and Daniel Diaz and Do, {Thao Huynh Phuong} and Do, {Thanh Chi} and Dziedzic, {Arkadiusz Marian} and Michael Ekholuenetale and Muhammed Elhadi and Emamian, {Mohammad Hassan} and Mehdi Emamverdi and Hossein Farrokhpour and Getahun Fetensa and Florian Fischer and Ali Forouhari and Fowobaje, {Kayode Raphael} and Gandhi, {Aravind P.} and Gebregergis, {Miglas W. W.} and Goulart, {B{\'a}rbara Niegia Garcia} and Gudeta, {Mesay Dechasa} and Sapna Gupta and Gupta, {Vivek Kumar} and Gupta, {Veer Bala} and Golnaz Heidari and Hong, {Sung Hwi} and Huynh, {Hong Han} and Ibitoye, {Segun Emmanuel} and Ilic, {Irena M.} and Mustapha Immurana and Jayapal, {Sathish Kumar} and Nitin Joseph and Joshua, {Charity Ehimwenma} and Himal Kandel and Karaye, {Ibraheem M.} and Hengameh Kasraei and Kebebew, {Getu Mosisa} and KhalafAlla, {Mahmoud Tawfik} and Sudarshan Khanal and Khatib, {Mahalaqua Nazli} and Kewal Krishan and Chandrakant Lahariya and Lim, {Stephen S.} and Marzo, {Roy Rillera} and Andrea Maugeri and Yang Meng and Tomislav Mestrovic and Manish Mishra and Mohamed, {Nouh Saad} and Hoda Mojiri-forushani and Mokdad, {Ali H.} and Hamed Momeni-Moghaddam and Fateme Montazeri and Admir Mulita and Murray, {Christopher J. L.} and Foodani, {Mahdi Nabi} and Naik, {Ganesh R.} and Natto, {Zuhair S.} and Nayak, {Biswa Prakash} and Mohammad Negaresh and Hadush Negash and Nguyen, {Dang H.} and Bogdan Oancea and Olagunju, {Andrew T.} and Olatubi, {Matthew Idowu} and Osman, {Wael M. S.} and Osuagwu, {Uchechukwu Levi} and Padubidri, {Jagadish Rao} and Shahina Pardhan and Seoyeon Park and Jay Patel and Arokiasamy Perianayagam and Pham, {Hoang Tran} and Prates, {Elton Junio Sady} and Ibrahim Qattea and Fakher Rahim and Mosiur Rahman and Deepthi Rapaka and Salman Rawaf and Nazila Rezaei and Priyanka Roy and Basema Saddik and Umar Saeed and Safi, {Sher Zaman} and Sare Safi and Sakshaug, {Joseph W.} and Saleh, {Mohamed A.} and Samuel, {Vijaya Paul} and Samy, {Abdallah M.} and Aswini Saravanan and Allen Seylani and Shaikh, {Masood Ali} and Shamim, {Muhammad Aaqib} and Mohammed Shannawaz and Shashamo, {Bereket Beyene} and Maryam Shayan and Aminu Shittu and Siddig, {Emmanuel Edwar} and Singh, {Jasvinder A.} and Yonatan Solomon and Sousa, {Ra{\'u}l A. R. C.} and Tabatabaei, {Seyyed Mohammad} and Mohammad Tabish and Ticoalu, {Jansje Henny Vera} and Toma, {Temesgen Mohammed} and Aristidis Tsatsakis and Tsegay, {Guesh Mebrahtom} and Rohollah Valizadeh and Maria Viskadourou and Wassie, {Gizachew Tadesse} and Wickramasinghe, {Nuwan Darshana} and Yon, {Dong Keon} and Yuyi You and Steinmetz, {Jaimie D.}",

note = "Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2024",

month = aug,

doi = "10.1038/s41433-024-02995-5",

language = "English",

volume = "38",

pages = "2036--2046",

journal = "Eye (Basingstoke)",

issn = "0950-222X",

publisher = "Springer, Springer Nature",

number = "11",

}

Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020. / Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators.
In: Eye (Basingstoke), Vol. 38, No. 11, 08.2024, p. 2036-2046.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Global estimates on the number of people blind or visually impaired by glaucoma

T2 - a meta-analysis from 2000 to 2020

AU - Vision Loss Expert Group of the Global Burden of Disease Study

AU - Bourne, Rupert R. A.

AU - Jonas, Jost B.

AU - Friedman, David

AU - Nangia, Vinay

AU - Bron, Alain M.

AU - Tapply, Ian

AU - Fernandes, Arthur G.

AU - Cicinelli, Maria Vittoria

AU - Arrigo, Alessandro

AU - Leveziel, Nicolas

AU - Resnikoff, Serge

AU - Taylor, Hugh R.

AU - Sedighi, Tabassom

AU - Bikbov, Mukkharram M.

AU - Braithwaite, Tasanee

AU - Cheng, Ching-Yu

AU - Congdon, Nathan

AU - Del Monte, Monte A.

AU - Ehrlich, Joshua R.

AU - Fricke, Tim

AU - Furtado, João M.

AU - Gazzard, Gus

AU - George, Ronnie

AU - Hartnett, M. Elizabeth

AU - Kahloun, Rim

AU - Kempen, John H.

AU - Khairallah, Moncef

AU - Khanna, Rohit C.

AU - Kim, Judy E.

AU - Lansingh, Van Charles

AU - Leasher, Janet L.

AU - Naidoo, Kovin S.

AU - Nowak, Michal

AU - Pesudovs, Konrad

AU - Peto, Tunde

AU - Ramulu, Pradeep

AU - Topouzis, Fotis

AU - Tsilimbaris, Mitiadis

AU - Wang, Ya Xing

AU - Wang, Ningli

AU - Flaxman, Seth

AU - the GBD 2019 Blindness and Vision Impairment Collaborators

AU - Casson, Robert James

AU - Briant, Paul Svitil

AU - Vos, Theo

AU - Abate, Yohannes Habtegiorgis

AU - Abate, Melsew Dagne

AU - Dolatabadi, Zahra Abbasi

AU - Abdollahi, Mozhan

AU - Aboagye, Richard Gyan

AU - Abu-Gharbieh, Eman

AU - Aburuz, Salahdein

AU - Adnani, Qorinah Estiningtyas Sakilah

AU - Aghamiri, Shahin

AU - Ahinkorah, Bright Opoku

AU - Ahmad, Danish

AU - Ahmadieh, Hamid

AU - Ahmadzadeh, Hooman

AU - Ahmed, Ayman

AU - Alfaar, Ahmad Samir

AU - Alinia, Cyrus

AU - Almidani, Louay

AU - Amu, Hubert

AU - Androudi, Sofia

AU - Anil, Abhishek

AU - Arabloo, Jalal

AU - Areda, Damelash

AU - Ashraf, Tahira

AU - Bagherieh, Sara

AU - Baltatu, Ovidiu Constantin

AU - Baran, Mehmet Firat

AU - Barrow, Amadou

AU - Bashiri, Azadeh

AU - Bayileyegn, Nebiyou Simegnew

AU - Bazvand, Fatemeh

AU - Berhie, Alemshet Yirga

AU - Bhatti, Jasvinder Singh

AU - Birck, Marina G.

AU - Bitra, Veera R.

AU - Bozic, Marija M.

AU - Burkart, Katrin

AU - Bustanji, Yasser

AU - Butt, Zahid A.

AU - Cenderadewi, Muthia

AU - Chattu, Vijay Kumar

AU - Coberly, Kaleb

AU - Dadras, Omid

AU - Dai, Xiaochen

AU - Dascalu, Ana Maria

AU - Dastiridou, Anna

AU - Devanbu, Vinoth Gnana Chellaiyan

AU - Dhimal, Meghnath

AU - Diaz, Daniel

AU - Do, Thao Huynh Phuong

AU - Do, Thanh Chi

AU - Dziedzic, Arkadiusz Marian

AU - Ekholuenetale, Michael

AU - Elhadi, Muhammed

AU - Emamian, Mohammad Hassan

AU - Emamverdi, Mehdi

AU - Farrokhpour, Hossein

AU - Fetensa, Getahun

AU - Fischer, Florian

AU - Forouhari, Ali

AU - Fowobaje, Kayode Raphael

AU - Gandhi, Aravind P.

AU - Gebregergis, Miglas W. W.

AU - Goulart, Bárbara Niegia Garcia

AU - Gudeta, Mesay Dechasa

AU - Gupta, Sapna

AU - Gupta, Vivek Kumar

AU - Gupta, Veer Bala

AU - Heidari, Golnaz

AU - Hong, Sung Hwi

AU - Huynh, Hong Han

AU - Ibitoye, Segun Emmanuel

AU - Ilic, Irena M.

AU - Immurana, Mustapha

AU - Jayapal, Sathish Kumar

AU - Joseph, Nitin

AU - Joshua, Charity Ehimwenma

AU - Kandel, Himal

AU - Karaye, Ibraheem M.

AU - Kasraei, Hengameh

AU - Kebebew, Getu Mosisa

AU - KhalafAlla, Mahmoud Tawfik

AU - Khanal, Sudarshan

AU - Khatib, Mahalaqua Nazli

AU - Krishan, Kewal

AU - Lahariya, Chandrakant

AU - Lim, Stephen S.

AU - Marzo, Roy Rillera

AU - Maugeri, Andrea

AU - Meng, Yang

AU - Mestrovic, Tomislav

AU - Mishra, Manish

AU - Mohamed, Nouh Saad

AU - Mojiri-forushani, Hoda

AU - Mokdad, Ali H.

AU - Momeni-Moghaddam, Hamed

AU - Montazeri, Fateme

AU - Mulita, Admir

AU - Murray, Christopher J. L.

AU - Foodani, Mahdi Nabi

AU - Naik, Ganesh R.

AU - Natto, Zuhair S.

AU - Nayak, Biswa Prakash

AU - Negaresh, Mohammad

AU - Negash, Hadush

AU - Nguyen, Dang H.

AU - Oancea, Bogdan

AU - Olagunju, Andrew T.

AU - Olatubi, Matthew Idowu

AU - Osman, Wael M. S.

AU - Osuagwu, Uchechukwu Levi

AU - Padubidri, Jagadish Rao

AU - Pardhan, Shahina

AU - Park, Seoyeon

AU - Patel, Jay

AU - Perianayagam, Arokiasamy

AU - Pham, Hoang Tran

AU - Prates, Elton Junio Sady

AU - Qattea, Ibrahim

AU - Rahim, Fakher

AU - Rahman, Mosiur

AU - Rapaka, Deepthi

AU - Rawaf, Salman

AU - Rezaei, Nazila

AU - Roy, Priyanka

AU - Saddik, Basema

AU - Saeed, Umar

AU - Safi, Sher Zaman

AU - Safi, Sare

AU - Sakshaug, Joseph W.

AU - Saleh, Mohamed A.

AU - Samuel, Vijaya Paul

AU - Samy, Abdallah M.

AU - Saravanan, Aswini

AU - Seylani, Allen

AU - Shaikh, Masood Ali

AU - Shamim, Muhammad Aaqib

AU - Shannawaz, Mohammed

AU - Shashamo, Bereket Beyene

AU - Shayan, Maryam

AU - Shittu, Aminu

AU - Siddig, Emmanuel Edwar

AU - Singh, Jasvinder A.

AU - Solomon, Yonatan

AU - Sousa, Raúl A. R. C.

AU - Tabatabaei, Seyyed Mohammad

AU - Tabish, Mohammad

AU - Ticoalu, Jansje Henny Vera

AU - Toma, Temesgen Mohammed

AU - Tsatsakis, Aristidis

AU - Tsegay, Guesh Mebrahtom

AU - Valizadeh, Rohollah

AU - Viskadourou, Maria

AU - Wassie, Gizachew Tadesse

AU - Wickramasinghe, Nuwan Darshana

AU - Yon, Dong Keon

AU - You, Yuyi

AU - Steinmetz, Jaimie D.

N1 - Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2024/8

Y1 - 2024/8

N2 - Objectives: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. Methods: A systematic review and meta-analysis of published population studies and grey literature from 2000 to 2020 was carried out to estimate global and regional trends in number of people with vision loss due to glaucoma. Moderate or severe vision loss (MSVI) was defined as visual acuity of 6/60 or better but <6/18 (moderate) and visual acuity of 3/60 or better but <6/60 (severe vision loss). Blindness was defined as presenting visual acuity <3/60. Results: Globally, in 2020, 3.61 million people were blind and nearly 4.14 million were visually impaired by glaucoma. Glaucoma accounted for 8.39% (95% uncertainty intervals [UIs]: 6.54, 10.29) of all blindness and 1.41% (95% UI: 1.10, 1.75) of all MSVI. Regionally, the highest proportion of blindness relating to glaucoma was found in high-income countries (26.12% [95% UI: 20.72, 32.09]), while the region with the highest age-standardized prevalence of glaucoma-related blindness and MSVI was Sub-Saharan Africa. Between 2000 and 2020, global age-standardized prevalence of glaucoma-related blindness among adults ≥50 years decreased by 26.06% among males (95% UI: 25.87, 26.24), and by 21.75% among females (95% UI: 21.54, 21.96), while MSVI due to glaucoma increased by 3.7% among males (95% UI: 3.42, 3.98), and by 7.3% in females (95% UI: 7.01, 7.59). Conclusions: Within the last two decades, glaucoma has remained a major cause of blindness globally and regionally.

AB - Objectives: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. Methods: A systematic review and meta-analysis of published population studies and grey literature from 2000 to 2020 was carried out to estimate global and regional trends in number of people with vision loss due to glaucoma. Moderate or severe vision loss (MSVI) was defined as visual acuity of 6/60 or better but <6/18 (moderate) and visual acuity of 3/60 or better but <6/60 (severe vision loss). Blindness was defined as presenting visual acuity <3/60. Results: Globally, in 2020, 3.61 million people were blind and nearly 4.14 million were visually impaired by glaucoma. Glaucoma accounted for 8.39% (95% uncertainty intervals [UIs]: 6.54, 10.29) of all blindness and 1.41% (95% UI: 1.10, 1.75) of all MSVI. Regionally, the highest proportion of blindness relating to glaucoma was found in high-income countries (26.12% [95% UI: 20.72, 32.09]), while the region with the highest age-standardized prevalence of glaucoma-related blindness and MSVI was Sub-Saharan Africa. Between 2000 and 2020, global age-standardized prevalence of glaucoma-related blindness among adults ≥50 years decreased by 26.06% among males (95% UI: 25.87, 26.24), and by 21.75% among females (95% UI: 21.54, 21.96), while MSVI due to glaucoma increased by 3.7% among males (95% UI: 3.42, 3.98), and by 7.3% in females (95% UI: 7.01, 7.59). Conclusions: Within the last two decades, glaucoma has remained a major cause of blindness globally and regionally.

UR - http://www.scopus.com/inward/record.url?scp=85199541563&partnerID=8YFLogxK

U2 - 10.1038/s41433-024-02995-5

DO - 10.1038/s41433-024-02995-5

M3 - Article

C2 - 38565601

AN - SCOPUS:85199541563

SN - 0950-222X

VL - 38

SP - 2036

EP - 2046

JO - Eye (Basingstoke)

JF - Eye (Basingstoke)

IS - 11

ER -

Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020

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