GlucoTRIG: a novel tool to determine the nutritional quality of foods and meals in general population

Rohith N. Thota, Paul J. Moughan, Harjinder Singh, Manohar L. Garg

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Background: This study aimed to develop a novel criterion, GlucoTRIG, to rank meals for healthiness, that considers both glycaemic (serum insulin) and lipaemic (serum triglycerides) responses. Methods: Healthy volunteers (n = 10) were recruited with the aim of deriving a standard GlucoTRIG value for a reference meal. Volunteers consumed the reference meal (2 regular slices of wholemeal bread; 250 mL chocolate flavoured milk; 7 g butter and 11 g peanut butter) comprising of carbohydrate, fat and protein (41, 40 and 16% energy respectively) on three different occasions with a minimum washout period of 3 days. The GlucoTRIG value was determined as the difference between the product of insulin and triglyceride obtained from venous blood samples at baseline and the product of insulin and triglyceride at 180 min. Results: There were no significant differences in the participants’ dietary intakes and their metabolic parameters between three visits (P > 0.005). The GlucoTRIG value obtained from three mean values of the reference meal was found to be 19 ± 3.5. There were no significant (P = 0.2303) differences observed between the GlucoTRIG values for the three visits. Conclusion: GlucoTRIG, consisting of both glycaemic and lipaemic responses, may be a physiologically relevant tool to rank foods and meals for reducing the risk of metabolic diseases. Trial registration: ACTRN12619000973112.
Original languageEnglish
Article number83
Pages (from-to)1-10
Number of pages10
JournalLipids in Health and Disease
Publication statusPublished - 4 May 2020
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Composite meals
  • Ranking criteria
  • GlucoTRIG
  • Insulin
  • Triglycerides
  • Macronutrients
  • Nutrient profiling
  • Diet
  • Metabolic disease


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