Glutamate in spinally projecting neurons of the rostral ventral medulla

Jane Minson*, Paul Pilowsky, Ida Llewellyn-Smith, Takeshi Kaneko, Vimal Kapoor, John Chalmers

*Corresponding author for this work

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Abstract

    Phosphate activated glutaminase (PAG), an enzyme of glutamate synthesis, was localized by immunohistochemistry in all PNMT-immunoreactive and all serotonin-immunoreactive neurons in the rostral ventral medulla of the rat. Between 71 and 83% of bulbospinal neurons localised in the rostral ventral medulla projecting to the intermediolateral cell column in the upper thoracic spinal cord contained PAG immunoreactivity. Of these bulbospinal PAG-immunoreactive neurons 17-27% contained PNMT immunoreactivity and 9-16% contained serotonin immunoreactivity. Other bulbospinal PAG-immunoreactive neurons (60-70%) contained neither PNMT- nor serotonin immunoreactivity. The results provide anatomical evidence suggestive of a glutamatergic input to the sympathetic preganglionic neurons of the spinal cord arising from different populations of neurons located in the rostral ventral medulla.

    Original languageEnglish
    Pages (from-to)326-331
    Number of pages6
    JournalBrain Research
    Volume555
    Issue number2
    DOIs
    Publication statusPublished - 2 Aug 1991

    Keywords

    • Bulbospinal
    • Cholera toxin B
    • Phosphate activated glutaminase
    • PNMT
    • Rat
    • Rostral ventrolateral medulla
    • Serotonin
    • Sympathetic preganglionic neuron

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