Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer

a matched historical control study

Lucy Jankova, Graham Robertson, Charles Chan, King L. Tan, Maija Kohonen-Corish, Caroline L S Fung, Candice Clarke, Betty P C Lin, Mark Molloy, Pierre H. Chapuis, Les Bokey, Owen F. Dent*, Stephen J. Clarke

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: This study examined the association between overall survival and Glutathione S-transferase Pi (GST Pi) expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy.Methods: Patients were drawn from a hospital registry of colorectal cancer resections. Those receiving chemotherapy after it was introduced in 1992 were compared with an age and sex matched control group from the preceding period. GST Pi expression was assessed by immunohistochemistry. Overall survival was analysed by the Kaplan-Meier method and Cox regression.Results: From an initial 104 patients treated with chemotherapy and 104 matched controls, 26 were excluded because of non-informative immunohistochemistry, leaving 95 in the treated group and 87 controls. Survival did not differ significantly among patients with low GST Pi who did or did not receive chemotherapy and those with high GST Pi who received chemotherapy (lowest pair-wise p = 0.11) whereas patients with high GST Pi who did not receive chemotherapy experienced markedly poorer survival than any of the other three groups (all pair-wise p <0.01). This result was unaffected by GST Pi genotype.Conclusion: Stage C colon cancer patients with low GST Pi did not benefit from 5-fluourouracil-based adjuvant chemotherapy whereas those with high GST Pi did.

Original languageEnglish
Article number196
Pages (from-to)1-9
Number of pages9
JournalBMC Cancer
Volume12
DOIs
Publication statusPublished - 28 May 2012

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