GlyConnect: glycoproteomics goes visual, interactive, and analytical

Davide Alocci, Julien Mariethoz, Alessandra Gastaldello, Elisabeth Gasteiger, Niclas G. Karlsson, Daniel Kolarich, Nicolle H. Packer, Frédérique Lisacek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Knowledge of glycoproteins, their site-specific glycosylation patterns, and the glycan structures that they present to their recognition partners in health and disease is gradually being built on using a range of experimental approaches. The data from these analyses are increasingly being standardized and presented in various sources, from supplemental tables in publications to localized servers in investigator laboratories. Bioinformatics tools are now needed to collect these data and enable the user to search, display, and connect glycomics and glycoproteomics to other sources of related proteomics, genomics, and interactomics information. We here introduce GlyConnect (https://glyconnect.expasy.org/), the central platform of the Glycomics@ExPASy portal for glycoinformatics. GlyConnect has been developed to gather, monitor, integrate, and visualize data in a user-friendly way to facilitate the interpretation of collected glycoscience data. GlyConnect is designed to accommodate and integrate multiple data types as they are increasingly produced.

Original languageEnglish
Pages (from-to)664-677
Number of pages14
JournalJournal of Proteome Research
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • data integration
  • database
  • software
  • glycoprotein
  • glycomics
  • glycoproteomics
  • glycan structure
  • mass spectrometry
  • data curation
  • data visualization

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