Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

John William Redmond (Inventor), Nicolle Hannah Packer (Inventor), Andrew Arthur Gooley (Inventor), Keith Leslie Williams (Inventor), Michael Batley (Inventor), Warren Charles Kerr (Inventor), Anthony Pisano (Inventor), Helen Joan Tweeddale (Inventor), Catherine Anne Cooper (Inventor)

Research output: Patent

Abstract

The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.
Original languageEnglish
Patent numberUS5831077
IPCC07H 5/06,C07H 1/00,C07H 1/08,C07H 9/00,C07H 9/06,C07H 11/00,C07K 1/00,C07K 1/12,C09B 29/00,C09B 29/50
Priority date9/12/93
Publication statusPublished - 3 Nov 1998

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  • Glycozylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

    Batley, M., Cooper, C. A., Gooley, A. A., Kett, W. C., Packer, N. H., Pisano, A., Redmond, J. W., Tweeddale, H. J. & Williams, K. L., 8 Jul 1999, IPC No. C07H 1/00, C07H 5/04, C07H 13/04, C07H 15/26, C07H 19/04, C07K 1/107, C07K 1/12, C08B 37/02, C08J 7/12, C09B 29/46, C09B 29/50, C09B 39/00, C09B 55/00, G01N 33/00, G01N 33/68, Patent No. AU1995012681, Priority date 9 Dec 1993, Priority No. AUPM2890

    Research output: Patent

    Open Access

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