TY - PAT
T1 - Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal
AU - Redmond, John William
AU - Packer, Nicolle Hannah
AU - Gooley, Andrew Arthur
AU - Williams, Keith Leslie
AU - Batley, Michael
AU - Kerr, Warren Charles
AU - Pisano, Anthony
AU - Tweeddale, Helen Joan
AU - Cooper, Catherine Anne
PY - 1998/11/3
Y1 - 1998/11/3
N2 - The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.
AB - The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.
M3 - Patent
M1 - US5831077
ER -