Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

John William Redmond; Nicolle Hannah Packer; Andrew Arthur Gooley; Keith Leslie Williams; Michael Batley; Warren Charles Kerr; Anthony Pisano; Helen Joan Tweeddale; Catherine Anne Cooper

Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

John William Redmond (Inventor), Nicolle Hannah Packer (Inventor), Andrew Arthur Gooley (Inventor), Keith Leslie Williams (Inventor), Michael Batley (Inventor), Warren Charles Kerr (Inventor), Anthony Pisano (Inventor), Helen Joan Tweeddale (Inventor), Catherine Anne Cooper (Inventor)

Faculty of Science and Engineering

Research output: Patent

Abstract

The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.

Original language	English
Patent number	US5831077
IPC	C07H 5/06,C07H 1/00,C07H 1/08,C07H 9/00,C07H 9/06,C07H 11/00,C07K 1/00,C07K 1/12,C09B 29/00,C09B 29/50
Priority date	9/12/93
Publication status	Published - 3 Nov 1998

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Glycozylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal
Batley, M. (Inventor), Cooper, C. A. (Inventor), Gooley, A. A. (Inventor), Kett, W. C. (Inventor), Packer, N. H. (Inventor), Pisano, A. (Inventor), Redmond, J. W. (Inventor), Tweeddale, H. J. (Inventor) & Williams, K. L. (Inventor), 8 Jul 1999, IPC No. C07H 1/00, C07H 5/04, C07H 13/04, C07H 15/26, C07H 19/04, C07K 1/107, C07K 1/12, C08B 37/02, C08J 7/12, C09B 29/46, C09B 29/50, C09B 39/00, C09B 55/00, G01N 33/00, G01N 33/68, Patent No. AU1995012681, Priority date 9 Dec 1993, Priority No. AUPM2890
Research output: Patent

Open Access

Cite this

@misc{f24d86d9b0364f0d850207560ee90239,

title = "Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal",

abstract = "The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars. ",

author = "Redmond, \{John William\} and Packer, \{Nicolle Hannah\} and Gooley, \{Andrew Arthur\} and Williams, \{Keith Leslie\} and Michael Batley and Kerr, \{Warren Charles\} and Anthony Pisano and Tweeddale, \{Helen Joan\} and Cooper, \{Catherine Anne\}",

year = "1998",

month = nov,

day = "3",

language = "English",

type = "Patent",

note = "US5831077; C07H 5/06,C07H 1/00,C07H 1/08,C07H 9/00,C07H 9/06,C07H 11/00,C07K 1/00,C07K 1/12,C09B 29/00,C09B 29/50",

}

TY - PAT

T1 - Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

AU - Redmond, John William

AU - Packer, Nicolle Hannah

AU - Gooley, Andrew Arthur

AU - Williams, Keith Leslie

AU - Batley, Michael

AU - Kerr, Warren Charles

AU - Pisano, Anthony

AU - Tweeddale, Helen Joan

AU - Cooper, Catherine Anne

PY - 1998/11/3

Y1 - 1998/11/3

N2 - The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.

AB - The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.

M3 - Patent

M1 - US5831077

ER -

Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

Abstract

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Research output

Glycozylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

Cite this