Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery

Vina R. Aldilla, Adam D. Martin*, Shashidhar Nizalapur, Christopher E. Marjo, Anne M. Rich, Kitty K. K. Ho, Lars M. Ittner, David St C. Black, Pall Thordarson, Naresh Kumar

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02-0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.

Original languageEnglish
Pages (from-to)6089-6098
Number of pages10
JournalJournal of Materials Chemistry B
Volume6
Issue number38
DOIs
Publication statusPublished - 14 Oct 2018

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    Aldilla, V. R., Martin, A. D., Nizalapur, S., Marjo, C. E., Rich, A. M., Ho, K. K. K., ... Kumar, N. (2018). Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery. Journal of Materials Chemistry B, 6(38), 6089-6098. https://doi.org/10.1039/C8TB01290C