TY - JOUR
T1 - Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery
AU - Aldilla, Vina R.
AU - Martin, Adam D.
AU - Nizalapur, Shashidhar
AU - Marjo, Christopher E.
AU - Rich, Anne M.
AU - Ho, Kitty K. K.
AU - Ittner, Lars M.
AU - Black, David St C.
AU - Thordarson, Pall
AU - Kumar, Naresh
PY - 2018/10/14
Y1 - 2018/10/14
N2 - In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02-0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.
AB - In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02-0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.
UR - https://www.scopus.com/pages/publications/85054354125
UR - http://purl.org/au-research/grants/arc/DP170100781
UR - http://purl.org/au-research/grants/arc/DP170100843
UR - http://purl.org/au-research/grants/nhmrc/1081916
UR - http://purl.org/au-research/grants/nhmrc/1132524
UR - http://purl.org/au-research/grants/nhmrc/1136241
U2 - 10.1039/C8TB01290C
DO - 10.1039/C8TB01290C
M3 - Article
AN - SCOPUS:85054354125
SN - 2050-7518
VL - 6
SP - 6089
EP - 6098
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 38
ER -