Grafting amino drugs to poly(styrene-alt-maleic anhydride) as a potential method for drug release

Ardeshir Khazaei, Shahnaz Saednia, Javad Saien, Masoud Kazem-Rostami, Mahdieh Sadeghpour, Maryam Kiani Borazjani, Fatemeh Abbasi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a 1H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 °C. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions.

Original languageEnglish
Pages (from-to)1109-1115
Number of pages7
JournalJournal of the Brazilian Chemical Society
Volume24
Issue number7
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Drug release
  • Kinetic
  • Poly(styrene-alt-maleic anhydride)
  • Polymer-drug
  • PSMA

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