Graphene oxide complex as a pH-sensitive antitumor drug

Rumei Cheng; Ruitao Zou; Shengju Ou; Rui Guo; Ruiying Yan; Haiyan Shi; Shanshan Yu; Xiaojian Li; Yexu Bu; Mimi Lin; Yong Liu; Liming Dai

doi:10.1039/c5py00047e

Graphene oxide complex as a pH-sensitive antitumor drug

Rumei Cheng, Ruitao Zou, Shengju Ou, Rui Guo, Ruiying Yan, Haiyan Shi, Shanshan Yu, Xiaojian Li, Yexu Bu, Mimi Lin, Yong Liu^*, Liming Dai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.

Original language	English
Pages (from-to)	2401-2406
Number of pages	6
Journal	Polymer Chemistry
Volume	6
Issue number	13
DOIs	https://doi.org/10.1039/c5py00047e
Publication status	Published - 7 Apr 2015

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title = "Graphene oxide complex as a pH-sensitive antitumor drug",

abstract = "A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.",

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T1 - Graphene oxide complex as a pH-sensitive antitumor drug

AU - Cheng, Rumei

AU - Zou, Ruitao

AU - Ou, Shengju

AU - Guo, Rui

AU - Yan, Ruiying

AU - Shi, Haiyan

AU - Yu, Shanshan

AU - Li, Xiaojian

AU - Bu, Yexu

AU - Lin, Mimi

AU - Liu, Yong

AU - Dai, Liming

PY - 2015/4/7

Y1 - 2015/4/7

N2 - A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.

AB - A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.

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U2 - 10.1039/c5py00047e

DO - 10.1039/c5py00047e

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SN - 1759-9954

VL - 6

SP - 2401

EP - 2406

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 13

ER -

Graphene oxide complex as a pH-sensitive antitumor drug

Abstract

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