Graphene oxide complex as a pH-sensitive antitumor drug

Rumei Cheng, Ruitao Zou, Shengju Ou, Rui Guo, Ruiying Yan, Haiyan Shi, Shanshan Yu, Xiaojian Li, Yexu Bu, Mimi Lin, Yong Liu*, Liming Dai

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.

    Original languageEnglish
    Pages (from-to)2401-2406
    Number of pages6
    JournalPolymer Chemistry
    Volume6
    Issue number13
    DOIs
    Publication statusPublished - 7 Apr 2015

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