Grey matter volume differences in the left caudate nucleus of people who stutter

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The cause of stuttering has many theoretical explanations. A number of research groups have suggested changes in the volume and/or function of the striatum as a causal agent. Two recent studies in children and one in adults who stutter (AWS) report differences in striatal volume compared that seen in controls; however, the laterality and nature of this anatomical volume difference is not consistent across studies. The current study investigated whether a reduction in striatal grey matter volume, comparable to that seen in children who stutter (CWS), would be found in AWS. Such a finding would support claims that an anatomical striatal anomaly plays a causal role in stuttering. We used voxel-based morphometry to examine the structure of the striatum in a group of AWS and compared it to that in a group of matched adult control subjects. Results showed a statistically significant group difference for the left caudate nucleus, with smaller mean volume in the group of AWS. The caudate nucleus, one of three main structures within the striatum, is thought to be critical for the planning and modulation of movement sequencing. The difference in striatal volume found here aligns with theoretical accounts of stuttering, which suggest it is a motor control disorder that arises from deficient articulatory movement selection and sequencing. Whilst the current study provides further evidence of a striatal volume difference in stuttering at the group level compared to controls, the significant overlap between AWS and controls suggests this difference is unlikely to be diagnostic of stuttering.

LanguageEnglish
Pages9-15
Number of pages7
JournalBrain and Language
Volume164
DOIs
Publication statusPublished - 1 Jan 2017

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Corpus Striatum
Stuttering
Caudate Nucleus
Group
Research Design
Gray Matter
Stutter
Grey Matter
Nucleus
diagnostic
planning
cause
Research
evidence
Striatum

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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title = "Grey matter volume differences in the left caudate nucleus of people who stutter",
abstract = "The cause of stuttering has many theoretical explanations. A number of research groups have suggested changes in the volume and/or function of the striatum as a causal agent. Two recent studies in children and one in adults who stutter (AWS) report differences in striatal volume compared that seen in controls; however, the laterality and nature of this anatomical volume difference is not consistent across studies. The current study investigated whether a reduction in striatal grey matter volume, comparable to that seen in children who stutter (CWS), would be found in AWS. Such a finding would support claims that an anatomical striatal anomaly plays a causal role in stuttering. We used voxel-based morphometry to examine the structure of the striatum in a group of AWS and compared it to that in a group of matched adult control subjects. Results showed a statistically significant group difference for the left caudate nucleus, with smaller mean volume in the group of AWS. The caudate nucleus, one of three main structures within the striatum, is thought to be critical for the planning and modulation of movement sequencing. The difference in striatal volume found here aligns with theoretical accounts of stuttering, which suggest it is a motor control disorder that arises from deficient articulatory movement selection and sequencing. Whilst the current study provides further evidence of a striatal volume difference in stuttering at the group level compared to controls, the significant overlap between AWS and controls suggests this difference is unlikely to be diagnostic of stuttering.",
author = "Sowman, {Paul F.} and Margaret Ryan and Johnson, {Blake W.} and Greg Savage and Stephen Crain and Elisabeth Harrison and Erin Martin and Hana Burianov{\'a}",
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Grey matter volume differences in the left caudate nucleus of people who stutter. / Sowman, Paul F.; Ryan, Margaret; Johnson, Blake W.; Savage, Greg; Crain, Stephen; Harrison, Elisabeth; Martin, Erin; Burianová, Hana.

In: Brain and Language, Vol. 164, 01.01.2017, p. 9-15.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Sowman,Paul F.

AU - Ryan,Margaret

AU - Johnson,Blake W.

AU - Savage,Greg

AU - Crain,Stephen

AU - Harrison,Elisabeth

AU - Martin,Erin

AU - Burianová,Hana

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