Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel

Vivek K. Gupta, Ammaji Rajala, Roger J. Daly, Raju V. S. Rajala

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Growth factor receptor-bound protein 14 (Grb14) is an adaptor protein that is involved in receptor tyrosine kinase signalling. In this study, we report that Grb14 interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate. Channel modulation is controlled by direct binding of the Grb14 Ras-associating domain with the carboxy-terminal region of CNGA1. We observed that the channel remains open in Grb14-mice that are exposed to light, suggesting that Grb14 is a normal physiological modulator of CNG channel function in vivo.
Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalEMBO Reports
Volume11
Issue number11
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • cyclic-nucleotide-gated channel
  • Grb14
  • photoreceptor cells
  • Ras-associating domain
  • tyrosine kinase signalling

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