The path towards next-generation IoT is fundamentally characterized by artificial intelligence-based sensors. However, there are still some open issues, such as efficiency, accuracy, privacy, data trustworthiness, quality etc., that need to be addressed. Therefore, this special issue aims to solicit original papers to solve these issues. Finally, some excellent papers are selected in this special issue from about 160 submissions. Due to the limitation of the editorial space, only 3 papers will be introduced here.