Guidance of neurite outgrowth on aligned electrospun polypyrrole/ poly(styrene-β-isobutylene-β-styrene) fiber platforms

Xiao Liu; Jun Chen; Kerry J. Gilmore; Michael J. Higgins; Yong Liu; Gordon G. Wallace

doi:10.1002/jbm.a.32675

Guidance of neurite outgrowth on aligned electrospun polypyrrole/ poly(styrene-β-isobutylene-β-styrene) fiber platforms

Xiao Liu, Jun Chen, Kerry J. Gilmore, Michael J. Higgins, Yong Liu, Gordon G. Wallace

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

The purpose of this work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-β- isobutylene-β-styrene) (SIBS) fibers. After successfully aligning the electroactive PPy/SIBS fibers based on our modified electrospinning method, we demonstrated that neurite outgrowth from PC12 cells could be highly orientated parallel to the aligned PPy/SIBS fibers. Physical interactions between the nerve cells and PPy/SIBS fibers through filopodia "sensing" were observed using atomic force microscopy. These observations indicate a role of contact guidance as a mechanism for the observed alignment. This work highlights the capacity for electroactive PPy/SIBS fibers to support and guide nerve cell differentiation through topographic cues, which is a highly desirable characteristic in medical implants for neurological applications.

Original language	English
Pages (from-to)	1004-1011
Number of pages	8
Journal	Journal of Biomedical Materials Research. Part A
Volume	94
Issue number	4
DOIs	https://doi.org/10.1002/jbm.a.32675
Publication status	Published - 15 Sept 2010

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AU - Liu, Yong

AU - Wallace, Gordon G.

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Guidance of neurite outgrowth on aligned electrospun polypyrrole/ poly(styrene-β-isobutylene-β-styrene) fiber platforms

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