Guidance of neurite outgrowth on aligned electrospun polypyrrole/ poly(styrene-β-isobutylene-β-styrene) fiber platforms

Xiao Liu, Jun Chen, Kerry J. Gilmore, Michael J. Higgins, Yong Liu, Gordon G. Wallace

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The purpose of this work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-β- isobutylene-β-styrene) (SIBS) fibers. After successfully aligning the electroactive PPy/SIBS fibers based on our modified electrospinning method, we demonstrated that neurite outgrowth from PC12 cells could be highly orientated parallel to the aligned PPy/SIBS fibers. Physical interactions between the nerve cells and PPy/SIBS fibers through filopodia "sensing" were observed using atomic force microscopy. These observations indicate a role of contact guidance as a mechanism for the observed alignment. This work highlights the capacity for electroactive PPy/SIBS fibers to support and guide nerve cell differentiation through topographic cues, which is a highly desirable characteristic in medical implants for neurological applications.

Original languageEnglish
Pages (from-to)1004-1011
Number of pages8
JournalJournal of Biomedical Materials Research. Part A
Volume94
Issue number4
DOIs
Publication statusPublished - 15 Sep 2010

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