Gut microbiome and immune responses in gastrointestinal cancer

Robyn Laube; Ken Liu

doi:10.1007/978-981-19-4492-5_11

Gut microbiome and immune responses in gastrointestinal cancer

Robyn Laube, Ken Liu^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The immune system plays an integral role in both the prevention and development of gastrointestinal malignancies. This effect is partially mediated via the gut microbiome, which ordinarily maintains a bidirectional homeostatic balance with the immune system. In addition to influencing the development of inflammation and malignancy, the microbiome can also affect the response to anti-cancer therapies and development of immune-mediated toxicities. Modulation of the gut microbiome via diet, antibiotics, probiotics and faecal microbiota transplantation are therefore also able to influence the course of a malignancy. Continued research in this field will pave the way towards the development of personalised medicine utilising individual microbial analysis to inform treatment decisions and enhance patient prognoses.

Original language	English
Title of host publication	Microbiome in gastrointestinal cancer
Editors	Jun Yu
Place of Publication	Singapore
Publisher	Springer Nature
Chapter	11
Pages	163-179
Number of pages	17
ISBN (Electronic)	9789811944925
ISBN (Print)	9789811944918
DOIs	https://doi.org/10.1007/978-981-19-4492-5_11
Publication status	Published - 1 Jan 2023

Keywords

Checkpoint inhibitor
Faecal microbiota transplantation Immunotherapy
Gastrointestinal malignancy, colorectal cancer Hepatocellular carcinoma
Immune system
Microbiome
Probiotics

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10.1007/978-981-19-4492-5_11

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abstract = "The immune system plays an integral role in both the prevention and development of gastrointestinal malignancies. This effect is partially mediated via the gut microbiome, which ordinarily maintains a bidirectional homeostatic balance with the immune system. In addition to influencing the development of inflammation and malignancy, the microbiome can also affect the response to anti-cancer therapies and development of immune-mediated toxicities. Modulation of the gut microbiome via diet, antibiotics, probiotics and faecal microbiota transplantation are therefore also able to influence the course of a malignancy. Continued research in this field will pave the way towards the development of personalised medicine utilising individual microbial analysis to inform treatment decisions and enhance patient prognoses.",

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AB - The immune system plays an integral role in both the prevention and development of gastrointestinal malignancies. This effect is partially mediated via the gut microbiome, which ordinarily maintains a bidirectional homeostatic balance with the immune system. In addition to influencing the development of inflammation and malignancy, the microbiome can also affect the response to anti-cancer therapies and development of immune-mediated toxicities. Modulation of the gut microbiome via diet, antibiotics, probiotics and faecal microbiota transplantation are therefore also able to influence the course of a malignancy. Continued research in this field will pave the way towards the development of personalised medicine utilising individual microbial analysis to inform treatment decisions and enhance patient prognoses.

KW - Checkpoint inhibitor

KW - Faecal microbiota transplantation Immunotherapy

KW - Gastrointestinal malignancy, colorectal cancer Hepatocellular carcinoma

KW - Immune system

KW - Microbiome

KW - Probiotics

UR - https://www.scopus.com/pages/publications/85160178126

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BT - Microbiome in gastrointestinal cancer

A2 - Yu, Jun

PB - Springer Nature

CY - Singapore

ER -

Gut microbiome and immune responses in gastrointestinal cancer

Abstract

Keywords

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