Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

Belinda M. Brown*, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Stephanie R. Rainey-Smith, Jeremiah J. Peiffer, Chengjie Xiong, Anne M. Fagan, Tammie Benzinger, Virginia Buckles, Kirk I. Erickson, Roger Clarnette, Tejal Shah, Colin L. Masters, Michael Weiner, Nigel Cairns, Martin Rossor, Neill R. Graff-Radford, Stephen Salloway, Jonathan Vöglein & 7 others Christoph Laske, James Noble, Peter R. Schofield, Randall J. Bateman, John C. Morris, Ralph N. Martins, The Dominantly Inherited Alzheimer Network

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods: In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression. Results: No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Discussion: Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

Original languageEnglish
Pages (from-to)1197-1206
Number of pages10
JournalAlzheimer's and Dementia
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

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Keywords

  • Alzheimer's disease
  • Amyloid β
  • Dementia
  • Genetics
  • Physical activity
  • Tau

Cite this

Brown, B. M., Sohrabi, H. R., Taddei, K., Gardener, S. L., Rainey-Smith, S. R., Peiffer, J. J., ... The Dominantly Inherited Alzheimer Network (2017). Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease. Alzheimer's and Dementia, 13(11), 1197-1206. https://doi.org/10.1016/j.jalz.2017.03.008