Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition

Peter B. Glover, Peter R. Ashton, Laura J. Childs, Alison Rodger, Michael Kercher, René M. Williams, Luisa De Cola, Zoe Pikramenou*

*Corresponding author for this work

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Luminescent Ln-Pt2 metallohairpin complexes have been developed, and their intercalative recognition with DNA has been demonstrated with linear dichroism spectroscopy. The heterotrimetallic complexes were formed in a one-step reaction, by assembly of an aminopolycarboxylate ligand, a platinum terpyridine unit, and the lanthanide salt. The metallohairpin complexes bear a neutral lanthanide moiety and two positively charged platinum-containing intercalating units. The Nd(III) analogues are luminescent in the near infrared, and this near-IR luminescence is retained upon binding to DNA. The DNA recognition was demonstrated by linear dichroism spectroscopy. The linear dichroism spectra suggested that the complexes bind perpendicular to the DNA helical axis, confirming intercalative recognition accompanied by dramatic stiffening of DNA, which suggests bis-intercalation of the complex.

Original languageEnglish
Pages (from-to)9918-9919
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number33
DOIs
Publication statusPublished - 20 Aug 2003
Externally publishedYes

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    Glover, P. B., Ashton, P. R., Childs, L. J., Rodger, A., Kercher, M., Williams, R. M., ... Pikramenou, Z. (2003). Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition. Journal of the American Chemical Society, 125(33), 9918-9919. https://doi.org/10.1021/ja029886s