Heart rate dependence of regional and local aortic pulse wave velocity in rats as a function of blood pressure

Bart Spronck, Isabella Tan, Koen Reesink, Dana Georgevsky, Tammo Delhaas, Alberto Avolio, Mark Butlin

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    Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV on BP, TT-PWV also depends on heart rate (HR). The present study aimed to also quantify the dependence of BH-PWV’s on HR, as a function of diastolic BP (DBP).

    Methods: Adult anaesthetised rats (n = 24) were randomly paced at 300–500 bpm, at 50-bpm steps. At each step, aortic TT-PWV (two pressure-tip catheters) and BH-PWV (pressure-tip catheter and ultrasound wall-tracking; abdominal aorta) were measured simultaneously, across a pharmacologically induced DBP range of 60–110 mmHg.

    Data from 9142 heart beats was analysed using mixed-effects modelling.

    Results: HR dependence of TT-PWV increased from 0.03 m/s/100 bpm at DBP = 60 mmHg to 0.06 m/s/100 bpm at DBP = 110 mmHg (both p ≤ 0.023). HR dependence of BH-PWV was 0.11 m/s/100 bpm at DBP = 60 and 85 mmHg, but paradoxically decreased to 0 at DBP = 110 mmHg (p = 0.686). This decrease in dependence is explicable in that standard BH-PWV uses an approximate derivative of pressure to diameter, which overestimates PWV with increasing pulse pressure (PP). PP decreases as HR increases, potentially causing a BH-PWV decrease with HR. This effect can be overcome by estimating the full pressure-diameter curve for each HR, and calculating the true derivative at DBP, yielding a BH-PWV that no longer shows significant HR dependence (p ≥ 0.076 at all DBPs).

    Conclusions: BH-PWV and TT-PWV show a different HR dependence, affected by DBP.
    Original languageEnglish
    Article number3.5
    Pages (from-to)54
    Number of pages1
    JournalArtery Research
    Issue numberC
    Publication statusPublished - Dec 2017
    EventAssociation for Research into Arterial Structure and Physiology Conference 2017: ARTERY 2017 - Pisa, Italy
    Duration: 12 Oct 201714 Oct 2017

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