Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Jennifer L. Cornish; Zeeshan Shahnawaz; Murray R. Thompson; Suzanna Wong; Kirsten C. Morley; Glenn E. Hunt; Iain S. McGregor

doi:10.1016/j.ejphar.2003.09.060

Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Jennifer L. Cornish, Zeeshan Shahnawaz, Murray R. Thompson, Suzanna Wong, Kirsten C. Morley, Glenn E. Hunt, Iain S. McGregor^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

59 Citations (Scopus)

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30°C) relative to normal laboratory temperature (21°C). In the intravenous drug self-administration paradigm, hot temperature (30°C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

Original language	English
Pages (from-to)	339-341
Number of pages	3
Journal	European Journal of Pharmacology
Volume	482
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2003.09.060
Publication status	Published - 15 Dec 2003
Externally published	Yes

Keywords

MDMA (3,4-Methylenedioxymethamphetamine)
Self-administration
Temperature

Access to Document

10.1016/j.ejphar.2003.09.060

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title = "Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats",

abstract = "3,4-Methylenedioxymethamphetamine (MDMA, {"}Ecstasy{"}) is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30°C) relative to normal laboratory temperature (21°C). In the intravenous drug self-administration paradigm, hot temperature (30°C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.",

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author = "Cornish, {Jennifer L.} and Zeeshan Shahnawaz and Thompson, {Murray R.} and Suzanna Wong and Morley, {Kirsten C.} and Hunt, {Glenn E.} and McGregor, {Iain S.}",

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T1 - Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

AU - Cornish, Jennifer L.

AU - Shahnawaz, Zeeshan

AU - Thompson, Murray R.

AU - Wong, Suzanna

AU - Morley, Kirsten C.

AU - Hunt, Glenn E.

AU - McGregor, Iain S.

PY - 2003/12/15

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AB - 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30°C) relative to normal laboratory temperature (21°C). In the intravenous drug self-administration paradigm, hot temperature (30°C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

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