Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

Jennifer L. Cornish, Zeeshan Shahnawaz, Murray R. Thompson, Suzanna Wong, Kirsten C. Morley, Glenn E. Hunt, Iain S. McGregor*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30°C) relative to normal laboratory temperature (21°C). In the intravenous drug self-administration paradigm, hot temperature (30°C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

Original languageEnglish
Pages (from-to)339-341
Number of pages3
JournalEuropean Journal of Pharmacology
Volume482
Issue number1-3
DOIs
Publication statusPublished - 15 Dec 2003
Externally publishedYes

Keywords

  • MDMA (3,4-Methylenedioxymethamphetamine)
  • Self-administration
  • Temperature

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