Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture

Alberto Avolio; Azadeh Farnoush; Michael Morgan; Yi Qian

doi:10.1109/IEMBS.2009.5335033

Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture

Alberto Avolio^*, Azadeh Farnoush, Michael Morgan, Yi Qian

^*Corresponding author for this work

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

11 Citations (Scopus)

71 Downloads (Pure)

Abstract

Surgical decisions on treatment of cerebral aneurysms are based predominantly on aneurysm size. This study has assessed the influence of parent vessel geometry on intra-aneurysmal flow patterns and mass flow rate using computational fluid dynamics and finite element modeling of straight and curved vessels feeding saccular aneurysms of varying size and aspect ratio. Simulation results have shown that aneurysms of similar shape and size but with curved parent vessels can have more than 2 fold increase in flow rate, with markedly different flow velocity patterns and development of secondary flows. These are significant hemodynamic factors that can contribute to increased risk of aneurysm rupture, in addition to aneurysm size. The dependency of parent vessel geometry is a function of aneurysm aspect ratio and shows minimal dependency at an aspect ratio of 1.68. These findings could be used for improved quantification of risk of rupture of cerebral aneurysms detected from clinical imaging modalities and to aid surgical decision making.

Original language	English
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Place of Publication	Piscataway, N.J
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	2351-2353
Number of pages	3
ISBN (Print)	9781424432967
DOIs	https://doi.org/10.1109/IEMBS.2009.5335033
Publication status	Published - 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: 2 Sept 2009 → 6 Sept 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country/Territory	United States
City	Minneapolis, MN
Period	2/09/09 → 6/09/09

Bibliographical note

Copyright 2009 IEEE. Reprinted from EMBC 2009 : Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "engineering the future of biomedicine" : 2-6 September, 2009, Hilton Minneapolis, Minnesota. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Macquarie Universityâ€™s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

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Avolio, A., Farnoush, A., Morgan, M., & Qian, Y. (2009). Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 2351-2353). Article 5335033 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/IEMBS.2009.5335033

Avolio, Alberto ; Farnoush, Azadeh ; Morgan, Michael et al. / Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. Piscataway, N.J : Institute of Electrical and Electronics Engineers (IEEE), 2009. pp. 2351-2353

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abstract = "Surgical decisions on treatment of cerebral aneurysms are based predominantly on aneurysm size. This study has assessed the influence of parent vessel geometry on intra-aneurysmal flow patterns and mass flow rate using computational fluid dynamics and finite element modeling of straight and curved vessels feeding saccular aneurysms of varying size and aspect ratio. Simulation results have shown that aneurysms of similar shape and size but with curved parent vessels can have more than 2 fold increase in flow rate, with markedly different flow velocity patterns and development of secondary flows. These are significant hemodynamic factors that can contribute to increased risk of aneurysm rupture, in addition to aneurysm size. The dependency of parent vessel geometry is a function of aneurysm aspect ratio and shows minimal dependency at an aspect ratio of 1.68. These findings could be used for improved quantification of risk of rupture of cerebral aneurysms detected from clinical imaging modalities and to aid surgical decision making.",

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Avolio, A, Farnoush, A, Morgan, M & Qian, Y 2009, Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5335033, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, N.J, pp. 2351-2353, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2/09/09. https://doi.org/10.1109/IEMBS.2009.5335033

Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture. / Avolio, Alberto; Farnoush, Azadeh; Morgan, Michael et al.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. Piscataway, N.J: Institute of Electrical and Electronics Engineers (IEEE), 2009. p. 2351-2353 5335033.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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T1 - Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture

AU - Avolio, Alberto

AU - Farnoush, Azadeh

AU - Morgan, Michael

AU - Qian, Yi

N1 - Copyright 2009 IEEE. Reprinted from EMBC 2009 : Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "engineering the future of biomedicine" : 2-6 September, 2009, Hilton Minneapolis, Minnesota. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Macquarie Universityâ€™s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

PY - 2009

Y1 - 2009

N2 - Surgical decisions on treatment of cerebral aneurysms are based predominantly on aneurysm size. This study has assessed the influence of parent vessel geometry on intra-aneurysmal flow patterns and mass flow rate using computational fluid dynamics and finite element modeling of straight and curved vessels feeding saccular aneurysms of varying size and aspect ratio. Simulation results have shown that aneurysms of similar shape and size but with curved parent vessels can have more than 2 fold increase in flow rate, with markedly different flow velocity patterns and development of secondary flows. These are significant hemodynamic factors that can contribute to increased risk of aneurysm rupture, in addition to aneurysm size. The dependency of parent vessel geometry is a function of aneurysm aspect ratio and shows minimal dependency at an aspect ratio of 1.68. These findings could be used for improved quantification of risk of rupture of cerebral aneurysms detected from clinical imaging modalities and to aid surgical decision making.

AB - Surgical decisions on treatment of cerebral aneurysms are based predominantly on aneurysm size. This study has assessed the influence of parent vessel geometry on intra-aneurysmal flow patterns and mass flow rate using computational fluid dynamics and finite element modeling of straight and curved vessels feeding saccular aneurysms of varying size and aspect ratio. Simulation results have shown that aneurysms of similar shape and size but with curved parent vessels can have more than 2 fold increase in flow rate, with markedly different flow velocity patterns and development of secondary flows. These are significant hemodynamic factors that can contribute to increased risk of aneurysm rupture, in addition to aneurysm size. The dependency of parent vessel geometry is a function of aneurysm aspect ratio and shows minimal dependency at an aspect ratio of 1.68. These findings could be used for improved quantification of risk of rupture of cerebral aneurysms detected from clinical imaging modalities and to aid surgical decision making.

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DO - 10.1109/IEMBS.2009.5335033

M3 - Conference proceeding contribution

C2 - 19965184

AN - SCOPUS:77951003243

SN - 9781424432967

SP - 2351

EP - 2353

BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

PB - Institute of Electrical and Electronics Engineers (IEEE)

CY - Piscataway, N.J

T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Y2 - 2 September 2009 through 6 September 2009

ER -

Avolio A, Farnoush A, Morgan M, Qian Y. Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. Piscataway, N.J: Institute of Electrical and Electronics Engineers (IEEE). 2009. p. 2351-2353. 5335033 doi: 10.1109/IEMBS.2009.5335033

Hemodynamic models of cerebral aneurysms for assessment of effect of vessel geometry on risk of rupture

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