Background: Studies showing associations of increased levels of haemoglobin (Hb) and erythropoietin with elevated blood pressure have been mainly conducted in patient cohorts. The few reports for the normal population are restricted to healthy voluntary blood donors. Aim: To investigate the association between Hb levels and systolic (SBP) and diastolic (DBP) blood pressure in a large community-dwelling cohort with normal glucose metabolism. Methods: The study population comprised 9181 (3888 male) subjects (age 29–95 years) with normal glucose tolerance from the Xuhui District community of Shanghai. Hb, fasting plasma glucose, glycated haemoglobin A1c (HbA1c), hepatic and renal function, lipids, electrolytes and anthropometric parameters were measured. Normal glucose tolerance was defined as plasma glucose level ≤ 126 mg/dl and HbA1 < 6.5%. Results: Hb level was found to be positively but weakly correlated with SBP (r=0.075, P <0.001) and more strongly correlated with DBP (r=0.272, P < 0.001) in the cohort. The relationship was not affected by age, body mass index (BMI), serum creatinine (Cr) nor low density lipoprotein (LDL) in both males and females. Multivariate stepwise regression analysis showed age (β=0.556, P < 0.001), BMI (β =1.107, P < 0.001), Hb (β=0.082; P < 0.001), Cr (r= –0.032, P < 0.001), and LDL (r=1.023, P < 0.001) were independent predictors for SBP and Hb (β=0.168, P < 0.001), BMI (β=0.519, P=0.001), and LDL (β =0.331, P < 0.001) predictors for DBP. Conclusions: In a Chinese community-dwelling population with normal glucose metabolism, although Hb level is positively associated with both SBP and DBP, it has a much stronger association with DBP.
|Number of pages||1|
|Publication status||Published - Nov 2018|
|Event||High Blood Pressure Research Council of Australia Abstracts from the Joint HBPRCA, AAS and AVBS Meeting 2018 - Glenelg, Australia|
Duration: 27 Nov 2018 → 30 Nov 2018
|Conference||High Blood Pressure Research Council of Australia Abstracts from the Joint HBPRCA, AAS and AVBS Meeting 2018|
|Period||27/11/18 → 30/11/18|