@article{1cbb01221a7b4a9da39f25bd345df301,
title = "Heritable DNA methylation marks associated with susceptibility to breast cancer",
abstract = "Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast cancer families. Here we report genome-wide DNA methylation measured in 210 peripheral blood DNA samples provided by family members using the Infinium HumanMethylation450. We develop and apply a new statistical method to identify heritable methylation marks based on complex segregation analysis. We estimate carrier probabilities for the 1000 most heritable methylation marks based on family structure, and we use Cox proportional hazards survival analysis to identify 24 methylation marks with corresponding carrier probabilities significantly associated with breast cancer. We replicate an association with breast cancer risk for four of the 24 marks using an independent nested case-control study. Here, we report a novel approach for identifying heritable DNA methylation marks associated with breast cancer risk.",
author = "Joo, {Jihoon E.} and Dowty, {James G.} and Milne, {Roger L.} and Wong, {Ee Ming} and Dugu{\'e}, {Pierre Antoine} and kConFab and Dallas English and Hopper, {John L.} and Goldgar, {David E.} and Giles, {Graham G.} and Southey, {Melissa C.} and Adrienne Sexton and Alice Christian and Alison Trainer and Allan Spigelman and Andrew Fellows and Andrew Shelling and {De Fazio}, Anna and Anneke Blackburn and Ashley Crook and Bettina Meiser and Briony Patterson and Christine Clarke and Christobel Saunders and Clare Hunt and Clare Scott and David Amor and Deborah Marsh and Edward Edkins and Elizabeth Salisbury and Eric Haan and Eveline Neidermayr and Finlay Macrae and Gelareh Farshid and Geoff Lindeman and Georgia Chenevix-Trench and Graham Mann and Grantley Gill and Heather Thorne and Ian Campbell and Ian Hickie and Ingrid Winship and Jack Goldblatt and James Flanagan and James Kollias and Jane Visvader and Jennifer Stone and Jessica Taylor and Jo Burke and Jodi Saunus and John Forbes and Jonathan Beesley and Judy Kirk and Juliet French and Kathy Tucker and Kathy Wu and Kelly Phillips and Lara Lipton and Leslie Andrews and Elizabeth Lobb and Logan Walker and Maira Kentwell and Amanda Spurdle and Margaret Cummings and Margaret Gleeson and Marion Harris and Mark Jenkins and Young, {Mary Anne} and Martin Delatycki and Mathew Wallis and Matthew Burgess and Melanie Price and Melissa Brown and Michael Bogwitz and Michael Field and Michael Friedlander and Michael Gattas and Mona Saleh and Nick Hayward and Nick Pachter and Paul Cohen and Pascal Duijf and Paul James and Peter Simpson and Peter Fong and Phyllis Butow and Rachael Williams and Richard Kefford and Rodney Scott and Rosemary Balleine and Sarah-Jane Dawson and Sheau Lok and Shona O'Connell and Sian Greening and Sophie Nightingale and Stacey Edwards and Stephen Fox and McLachlan, {Sue Anne} and Sunil Lakhani and Susan Thomas and Yoland Antill",
note = "Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-03058-6",
language = "English",
volume = "9",
pages = "1--12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer, Springer Nature",
number = "1",
}