Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju, Andrew M. Piggott, Zeinab Khalil, Paul V. Bernhardt, Robert J. Capon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC 50 = 18 and 14 μM, respectively).

Original languageEnglish
Pages (from-to)1063-1065
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number9
DOIs
Publication statusPublished - 29 Feb 2012
Externally publishedYes

Keywords

  • Benzothiazine ansamycin
  • Herbimycin A
  • Marine-derived Streptomyces
  • Natural products chemistry

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