Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju; Andrew M. Piggott; Zeinab Khalil; Paul V. Bernhardt; Robert J. Capon

doi:10.1016/j.tetlet.2011.12.064

Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju, Andrew M. Piggott, Zeinab Khalil, Paul V. Bernhardt, Robert J. Capon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC ₅₀ = 18 and 14 μM, respectively).

Original language	English
Pages (from-to)	1063-1065
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.064
Publication status	Published - 29 Feb 2012
Externally published	Yes

Keywords

Benzothiazine ansamycin
Herbimycin A
Marine-derived Streptomyces
Natural products chemistry

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10.1016/j.tetlet.2011.12.064

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title = "Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.",

abstract = "Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC 50 = 18 and 14 μM, respectively).",

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T2 - a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

AU - Raju, Ritesh

AU - Piggott, Andrew M.

AU - Khalil, Zeinab

AU - Bernhardt, Paul V.

AU - Capon, Robert J.

PY - 2012/2/29

Y1 - 2012/2/29

N2 - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC 50 = 18 and 14 μM, respectively).

AB - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC 50 = 18 and 14 μM, respectively).

KW - Benzothiazine ansamycin

KW - Herbimycin A

KW - Marine-derived Streptomyces

KW - Natural products chemistry

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M3 - Article

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SN - 0040-4039

VL - 53

SP - 1063

EP - 1065

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 9

ER -

Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

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Keywords

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