Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

Ritesh Raju; Andrew M. Piggott; Leticia X. Barrientos Diaz; Zeinab Khalil; Robert J. Capon

doi:10.1021/ol102162d

Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

Ritesh Raju, Andrew M. Piggott, Leticia X. Barrientos Diaz, Zeinab Khalil, Robert J. Capon

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC₅₀ activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.

Original language	English
Pages (from-to)	5158-5161
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1021/ol102162d
Publication status	Published - 19 Nov 2010
Externally published	Yes

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title = "Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.",

abstract = "Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC50 activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.",

author = "Ritesh Raju and Piggott, {Andrew M.} and {Barrientos Diaz}, {Leticia X.} and Zeinab Khalil and Capon, {Robert J.}",

year = "2010",

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doi = "10.1021/ol102162d",

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volume = "12",

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journal = "Organic Letters",

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publisher = "American Chemical Society",

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T2 - Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

AU - Raju, Ritesh

AU - Piggott, Andrew M.

AU - Barrientos Diaz, Leticia X.

AU - Khalil, Zeinab

AU - Capon, Robert J.

PY - 2010/11/19

Y1 - 2010/11/19

N2 - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC50 activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.

AB - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC50 activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.

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U2 - 10.1021/ol102162d

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JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

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