Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

Ritesh Raju, Andrew M. Piggott, Leticia X. Barrientos Diaz, Zeinab Khalil, Robert J. Capon

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC50 activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.

Original languageEnglish
Pages (from-to)5158-5161
Number of pages4
JournalOrganic Letters
Volume12
Issue number22
DOIs
Publication statusPublished - 19 Nov 2010
Externally publishedYes

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