Abstract
The interferon (IFN) system is one of the first lines of defense activated against invading viral pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of several interferon stimulated genes (ISGs), which work to limit viral replication and establish an overall anti-viral state. Herpes simplex virus type 1 is a ubiquitous human pathogen that has evolved to downregulate the IFN response and establish lifelong latent infection in sensory neurons of the host. This review will focus on the mechanisms by which the host innate immune system detects invading HSV-1 virions, the subsequent IFN response generated to limit viral infection, and the evasion strategies developed by HSV-1 to evade the immune system and establish latency in the host.
| Original language | English |
|---|---|
| Article number | 5150 |
| Pages (from-to) | 1-31 |
| Number of pages | 31 |
| Journal | International Journal of Molecular Sciences |
| Volume | 21 |
| Issue number | 14 |
| Early online date | 21 Jul 2020 |
| DOIs | |
| Publication status | Published - Jul 2020 |
| Externally published | Yes |
Bibliographical note
Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- Herpes simplex virus
- Immune evasion
- Innate immunity
- Interferon