Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase

John A. Kalaitzis, Bradley S. Moore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Heterologous expression of the actinorhodin polyketide synthase in the recombinant host Streptomyces lividans K4-114 led to the characterization of three new minor polyketides, the novel hexaketides BSM1 and BSM3 and 9′-hydroxyaloesaponarin II, in addition to known anthraquinone and aromatic octaketides. The structures of BSM1 and BSM3 imply that these compounds are derived from a C-5-reduced hexaketide intermediate, suggesting that the timing of the ketoreduction reaction in the actinorhodin biosynthetic pathway may take place during the polyketide elongation process rather than after the completion of the octaketide chain as previously suggested.

Original languageEnglish
Pages (from-to)1419-1422
Number of pages4
JournalJournal of Natural Products
Volume67
Issue number8
DOIs
Publication statusPublished - 2004
Externally publishedYes

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