Hidden hearing loss selectively impairs neural adaptation to loud sound environments

Warren Michael Henry Bakay, Lucy Anne Anderson, Jose Alberto Garcia-Lazaro, David McAlpine, Roland Schaette

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Exposure to even a single episode of loud noise can damage synapses between cochlear hair cells and auditory nerve fibres, causing hidden hearing loss (HHL) that is not detected by audiometry. Here we investigate the effects of noise-induced HHL on functional hearing by measuring the ability of neurons in the auditory midbrain of mice to adapt to sound environments containing quiet and loud periods. Neurons from noise-exposed mice show less capacity for adaptation to loud environments, convey less information about sound intensity in those environments, and adaptation to the longer-term statistical structure of fluctuating sound environments is impaired. Adaptation comprises a cascade of both threshold and gain adaptation. Although noise exposure only impairs threshold adaptation directly, the preserved function of gain adaptation surprisingly aggravates coding deficits for loud environments. These deficits might help to understand why many individuals with seemingly normal hearing struggle to follow a conversation in background noise.

LanguageEnglish
Article number4298
Pages1-11
Number of pages11
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 16 Oct 2018

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auditory defects
Audition
Hearing Loss
Acoustic waves
Noise
acoustics
Acoustic noise
Neurons
Hearing
hearing
neurons
Acoustic intensity
Auditory Hair Cells
mice
Noise-Induced Hearing Loss
audiometry
Audiometry
Cochlear Nerve
Aptitude
conversation

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Bakay, Warren Michael Henry ; Anderson, Lucy Anne ; Garcia-Lazaro, Jose Alberto ; McAlpine, David ; Schaette, Roland. / Hidden hearing loss selectively impairs neural adaptation to loud sound environments. In: Nature Communications. 2018 ; Vol. 9, No. 1. pp. 1-11.
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Hidden hearing loss selectively impairs neural adaptation to loud sound environments. / Bakay, Warren Michael Henry; Anderson, Lucy Anne; Garcia-Lazaro, Jose Alberto; McAlpine, David; Schaette, Roland.

In: Nature Communications, Vol. 9, No. 1, 4298, 16.10.2018, p. 1-11.

Research output: Contribution to journalArticleResearchpeer-review

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