Hidden hearing loss selectively impairs neural adaptation to loud sound environments

Warren Michael Henry Bakay, Lucy Anne Anderson, Jose Alberto Garcia-Lazaro, David McAlpine, Roland Schaette*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    16 Citations (Scopus)
    45 Downloads (Pure)

    Abstract

    Exposure to even a single episode of loud noise can damage synapses between cochlear hair cells and auditory nerve fibres, causing hidden hearing loss (HHL) that is not detected by audiometry. Here we investigate the effects of noise-induced HHL on functional hearing by measuring the ability of neurons in the auditory midbrain of mice to adapt to sound environments containing quiet and loud periods. Neurons from noise-exposed mice show less capacity for adaptation to loud environments, convey less information about sound intensity in those environments, and adaptation to the longer-term statistical structure of fluctuating sound environments is impaired. Adaptation comprises a cascade of both threshold and gain adaptation. Although noise exposure only impairs threshold adaptation directly, the preserved function of gain adaptation surprisingly aggravates coding deficits for loud environments. These deficits might help to understand why many individuals with seemingly normal hearing struggle to follow a conversation in background noise.

    Original languageEnglish
    Article number4298
    Pages (from-to)1-11
    Number of pages11
    JournalNature Communications
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 16 Oct 2018

    Bibliographical note

    Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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