High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease

Steve Pedrini, Pratishtha Chatterjee, Eugene Hone, Ralph N. Martins*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    High-density lipoproteins (HDL) are a heterogeneous class of molecules whose main function is to remove excess cholesterol through a mechanism called reverse transport, in which cholesterol is transported from peripheral organs and from arterial foam cells to the liver, where it is subsequently eliminated with bile. While its ability to eliminate excess cholesterol has always been viewed as its main feature, its beneficial effects go beyond this single effect. Many of the proteins that are associated with HDL are responsible for anti-oxidant and anti-inflammatory properties. These proteins that are associated with HDL during its generation and remodelling, are referred to as 'protein cargo', which has been extensively analysed by mass spectrometry analysis in healthy and diseased individuals. In this review, we discuss the pathway that leads to HDL formation and its subsequent remodelling and catabolism with regards to the possible involvement of HDL 'protein cargo' in Alzheimer's disease.

    Original languageEnglish
    Pages (from-to)343-377
    Number of pages35
    JournalJournal of Neurochemistry
    Volume159
    Issue number2
    DOIs
    Publication statusPublished - Oct 2021

    Keywords

    • Alzheimer's Disease
    • Amyloid-β
    • Cholesterol metabolism
    • HDL
    • lipid transport

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