High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii)

Yuanyuan Cheng, Hannah V. Siddle, Stephan Beck, Mark D B Eldridge, Katherine Belov*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

High levels of MHC diversity are crucial for immunological fitness of populations, with island populations particularly susceptible to loss of genetic diversity. In this study, the level of MHC class II DBB diversity was examined in tammar wallabies (Macropus eugenii) from Kangaroo Island by genotyping class II-linked microsatellite loci and sequencing of DBB genes. Here we show that the tammar wallaby has at least four expressed MHC class II DBB loci and extensive genetic variation in the peptide-binding region of the DBB genes. These results contradict early studies which suggested that wallabies lacked MHC class II diversity and demonstrate that, in spite of the long-term isolation on an offshore island, this population of wallabies has a high level of DBB diversity.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalImmunogenetics
Volume61
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Keywords

  • Genetic variation
  • Marsupial
  • MHC Class II
  • MHC-linked microsatellite
  • Tammar wallaby

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