High prevalence of Crohn disease and ulcerative colitis among older people in Sydney

Aviv Pudipeddi; Jeffrey Liu; Viraj Kariyawasam; Thomas J. Borody; James L. Cowlishaw; Charles McDonald; Peter Katelaris; Grace Chapman; Crispin Corte; Daniel A. Lemberg; Cheng H. Lee; Anil Keshava; John Napoli; Robert Clancy; Webber Chan; Sudarshan Paramsothy; Rupert Leong

doi:10.5694/mja2.50910

High prevalence of Crohn disease and ulcerative colitis among older people in Sydney

Aviv Pudipeddi^*, Jeffrey Liu, Viraj Kariyawasam, Thomas J. Borody, James L. Cowlishaw, Charles McDonald, Peter Katelaris, Grace Chapman, Crispin Corte, Daniel A. Lemberg, Cheng H. Lee, Anil Keshava, John Napoli, Robert Clancy, Webber Chan, Sudarshan Paramsothy, Rupert Leong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objectives: To determine the age-standardised prevalence of inflammatory bowel disease (IBD) in a metropolitan area of Sydney, with a focus on its prevalence among older people.

Design, setting: Population-based epidemiological study of people with IBD in the City of Canada Bay, a local government area in the inner west of Sydney, during 1 March 2016 - 10 November 2016.

Participants: Patients diagnosed with confirmed IBD according to the Copenhagen or revised Porto criteria.

Main outcome measures: Crude prevalence of IBD, including Crohn disease and ulcerative colitis; age-standardised prevalence of IBD, based on the World Health Organization standard population; prevalence rates among people aged 65 years or more.

Results: The median age of 364 people with IBD was 47 years (IQR, 34-62 years); 185 were women (50.8%). The crude IBD prevalence rate was 414 cases (95% CI, 371-456 cases) per 100 000 population; the age-standardised rate was 348 cases (95% CI, 312-385 cases) per 100 000 population. The age-standardised rate for Crohn disease was 166 cases (95% CI, 141-192 cases) per 100 000 population; for ulcerative colitis, 148 cases (95% CI, 124-171 cases) per 100 000 population. The IBD prevalence rate in people aged 65 years or more was 612 cases (95% CI, 564-660 cases) per 100 000, and for those aged 85 years or more, 891 cases (95% CI, 833-949 cases) per 100 000; for people under 65, the rate was 380 cases (95% CI, 342-418 cases) per 100 000.

Conclusions: We found that the prevalence of confirmed IBD in a metropolitan sample was highest among older people. Challenges for managing older patients with IBD include higher rates of comorbid conditions, polypharmacy, and cognitive decline, and the immunosuppressive nature of standard therapies for IBD.

Original language	English
Pages (from-to)	365-370
Number of pages	6
Journal	Medical Journal of Australia
Volume	214
Issue number	8
Early online date	27 Jan 2021
DOIs	https://doi.org/10.5694/mja2.50910
Publication status	Published - May 2021
Externally published	Yes

Keywords

Crohn's disease
Epidemiology
Inflammatory bowel diseases

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10.5694/mja2.50910

Cite this

Pudipeddi, A., Liu, J., Kariyawasam, V., Borody, T. J., Cowlishaw, J. L., McDonald, C., Katelaris, P., Chapman, G., Corte, C., Lemberg, D. A., Lee, C. H., Keshava, A., Napoli, J., Clancy, R., Chan, W., Paramsothy, S., & Leong, R. (2021). High prevalence of Crohn disease and ulcerative colitis among older people in Sydney. Medical Journal of Australia, 214(8), 365-370. https://doi.org/10.5694/mja2.50910

@article{15df4af9b83f4e828754e746db96c443,

title = "High prevalence of Crohn disease and ulcerative colitis among older people in Sydney",

abstract = "Objectives: To determine the age-standardised prevalence of inflammatory bowel disease (IBD) in a metropolitan area of Sydney, with a focus on its prevalence among older people.Design, setting: Population-based epidemiological study of people with IBD in the City of Canada Bay, a local government area in the inner west of Sydney, during 1 March 2016 - 10 November 2016.Participants: Patients diagnosed with confirmed IBD according to the Copenhagen or revised Porto criteria.Main outcome measures: Crude prevalence of IBD, including Crohn disease and ulcerative colitis; age-standardised prevalence of IBD, based on the World Health Organization standard population; prevalence rates among people aged 65 years or more.Results: The median age of 364 people with IBD was 47 years (IQR, 34-62 years); 185 were women (50.8%). The crude IBD prevalence rate was 414 cases (95% CI, 371-456 cases) per 100 000 population; the age-standardised rate was 348 cases (95% CI, 312-385 cases) per 100 000 population. The age-standardised rate for Crohn disease was 166 cases (95% CI, 141-192 cases) per 100 000 population; for ulcerative colitis, 148 cases (95% CI, 124-171 cases) per 100 000 population. The IBD prevalence rate in people aged 65 years or more was 612 cases (95% CI, 564-660 cases) per 100 000, and for those aged 85 years or more, 891 cases (95% CI, 833-949 cases) per 100 000; for people under 65, the rate was 380 cases (95% CI, 342-418 cases) per 100 000.Conclusions: We found that the prevalence of confirmed IBD in a metropolitan sample was highest among older people. Challenges for managing older patients with IBD include higher rates of comorbid conditions, polypharmacy, and cognitive decline, and the immunosuppressive nature of standard therapies for IBD.",

keywords = "Crohn's disease, Epidemiology, Inflammatory bowel diseases",

author = "Aviv Pudipeddi and Jeffrey Liu and Viraj Kariyawasam and Borody, {Thomas J.} and Cowlishaw, {James L.} and Charles McDonald and Peter Katelaris and Grace Chapman and Crispin Corte and Lemberg, {Daniel A.} and Lee, {Cheng H.} and Anil Keshava and John Napoli and Robert Clancy and Webber Chan and Sudarshan Paramsothy and Rupert Leong",

year = "2021",

month = may,

doi = "10.5694/mja2.50910",

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pages = "365--370",

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Pudipeddi, A, Liu, J, Kariyawasam, V, Borody, TJ, Cowlishaw, JL, McDonald, C, Katelaris, P, Chapman, G, Corte, C, Lemberg, DA, Lee, CH, Keshava, A, Napoli, J, Clancy, R, Chan, W, Paramsothy, S & Leong, R 2021, 'High prevalence of Crohn disease and ulcerative colitis among older people in Sydney', Medical Journal of Australia, vol. 214, no. 8, pp. 365-370. https://doi.org/10.5694/mja2.50910

TY - JOUR

T1 - High prevalence of Crohn disease and ulcerative colitis among older people in Sydney

AU - Pudipeddi, Aviv

AU - Liu, Jeffrey

AU - Kariyawasam, Viraj

AU - Borody, Thomas J.

AU - Cowlishaw, James L.

AU - McDonald, Charles

AU - Katelaris, Peter

AU - Chapman, Grace

AU - Corte, Crispin

AU - Lemberg, Daniel A.

AU - Lee, Cheng H.

AU - Keshava, Anil

AU - Napoli, John

AU - Clancy, Robert

AU - Chan, Webber

AU - Paramsothy, Sudarshan

AU - Leong, Rupert

PY - 2021/5

Y1 - 2021/5

N2 - Objectives: To determine the age-standardised prevalence of inflammatory bowel disease (IBD) in a metropolitan area of Sydney, with a focus on its prevalence among older people.Design, setting: Population-based epidemiological study of people with IBD in the City of Canada Bay, a local government area in the inner west of Sydney, during 1 March 2016 - 10 November 2016.Participants: Patients diagnosed with confirmed IBD according to the Copenhagen or revised Porto criteria.Main outcome measures: Crude prevalence of IBD, including Crohn disease and ulcerative colitis; age-standardised prevalence of IBD, based on the World Health Organization standard population; prevalence rates among people aged 65 years or more.Results: The median age of 364 people with IBD was 47 years (IQR, 34-62 years); 185 were women (50.8%). The crude IBD prevalence rate was 414 cases (95% CI, 371-456 cases) per 100 000 population; the age-standardised rate was 348 cases (95% CI, 312-385 cases) per 100 000 population. The age-standardised rate for Crohn disease was 166 cases (95% CI, 141-192 cases) per 100 000 population; for ulcerative colitis, 148 cases (95% CI, 124-171 cases) per 100 000 population. The IBD prevalence rate in people aged 65 years or more was 612 cases (95% CI, 564-660 cases) per 100 000, and for those aged 85 years or more, 891 cases (95% CI, 833-949 cases) per 100 000; for people under 65, the rate was 380 cases (95% CI, 342-418 cases) per 100 000.Conclusions: We found that the prevalence of confirmed IBD in a metropolitan sample was highest among older people. Challenges for managing older patients with IBD include higher rates of comorbid conditions, polypharmacy, and cognitive decline, and the immunosuppressive nature of standard therapies for IBD.

AB - Objectives: To determine the age-standardised prevalence of inflammatory bowel disease (IBD) in a metropolitan area of Sydney, with a focus on its prevalence among older people.Design, setting: Population-based epidemiological study of people with IBD in the City of Canada Bay, a local government area in the inner west of Sydney, during 1 March 2016 - 10 November 2016.Participants: Patients diagnosed with confirmed IBD according to the Copenhagen or revised Porto criteria.Main outcome measures: Crude prevalence of IBD, including Crohn disease and ulcerative colitis; age-standardised prevalence of IBD, based on the World Health Organization standard population; prevalence rates among people aged 65 years or more.Results: The median age of 364 people with IBD was 47 years (IQR, 34-62 years); 185 were women (50.8%). The crude IBD prevalence rate was 414 cases (95% CI, 371-456 cases) per 100 000 population; the age-standardised rate was 348 cases (95% CI, 312-385 cases) per 100 000 population. The age-standardised rate for Crohn disease was 166 cases (95% CI, 141-192 cases) per 100 000 population; for ulcerative colitis, 148 cases (95% CI, 124-171 cases) per 100 000 population. The IBD prevalence rate in people aged 65 years or more was 612 cases (95% CI, 564-660 cases) per 100 000, and for those aged 85 years or more, 891 cases (95% CI, 833-949 cases) per 100 000; for people under 65, the rate was 380 cases (95% CI, 342-418 cases) per 100 000.Conclusions: We found that the prevalence of confirmed IBD in a metropolitan sample was highest among older people. Challenges for managing older patients with IBD include higher rates of comorbid conditions, polypharmacy, and cognitive decline, and the immunosuppressive nature of standard therapies for IBD.

KW - Crohn's disease

KW - Epidemiology

KW - Inflammatory bowel diseases

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U2 - 10.5694/mja2.50910

DO - 10.5694/mja2.50910

M3 - Article

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SN - 0025-729X

VL - 214

SP - 365

EP - 370

JO - Medical Journal of Australia

JF - Medical Journal of Australia

IS - 8

ER -

High prevalence of Crohn disease and ulcerative colitis among older people in Sydney

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