Abstract
We report on the high-resolution deep-tissue imaging using novel water-dispersible upconversion nanoparticles (UCNPs) β-NaYF4:Yb 3+:Tm3+. Luminescence from the UCNP embedded into tissue-mimicking phantoms at the depth of 4 mm epi-illuminated with 975-nm laser radiation was detected. Fiber-optic detection shows 2-times better resolution compared with that obtained using CCD-based imaging modality. The conversion efficiency of upconversion particles and their cytotoxicity to HeLa cells were also investigated and reported.
Original language | English |
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Title of host publication | Novel Biophotonic Techniques and Applications II |
Subtitle of host publication | Proceedings of SPIE |
Editors | Alex Vitkin, Arjen Amelink |
Place of Publication | Bellingham, WA |
Publisher | SPIE |
Pages | 1-8 |
Number of pages | 8 |
Volume | 8801 |
ISBN (Print) | 9780819496508 |
DOIs | |
Publication status | Published - 2013 |
Event | European Conference on Biomedical Optics, ECBO 2013 - Munich, Germany Duration: 12 May 2013 → 16 May 2013 |
Other
Other | European Conference on Biomedical Optics, ECBO 2013 |
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Country/Territory | Germany |
City | Munich |
Period | 12/05/13 → 16/05/13 |