High-resolution deep-tissue optical imaging using anti-Stokes phosphors

A. P. Popov, A. V. Karmenyan, A. V. Bykov, E. V. Khaydukov, A. V. Nechaev, O. A. Bibikova, V. Ya Panchenko, V. A. Semchishen, V. N. Seminogov, A. S. Akhmanov, V. I. Sokolov, M. T. Kinnunen, V. V. Tuchin, A. V. Zvyagin

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

5 Citations (Scopus)
30 Downloads (Pure)


We report on the high-resolution deep-tissue imaging using novel water-dispersible upconversion nanoparticles (UCNPs) β-NaYF4:Yb 3+:Tm3+. Luminescence from the UCNP embedded into tissue-mimicking phantoms at the depth of 4 mm epi-illuminated with 975-nm laser radiation was detected. Fiber-optic detection shows 2-times better resolution compared with that obtained using CCD-based imaging modality. The conversion efficiency of upconversion particles and their cytotoxicity to HeLa cells were also investigated and reported.

Original languageEnglish
Title of host publicationNovel Biophotonic Techniques and Applications II
Subtitle of host publicationProceedings of SPIE
EditorsAlex Vitkin, Arjen Amelink
Place of PublicationBellingham, WA
Number of pages8
ISBN (Print)9780819496508
Publication statusPublished - 2013
EventEuropean Conference on Biomedical Optics, ECBO 2013 - Munich, Germany
Duration: 12 May 201316 May 2013


OtherEuropean Conference on Biomedical Optics, ECBO 2013

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