Abstract
The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension. A Eulerian video magnification algorithm was used to extract retinal arterial and venous pulse amplitude from five Spontaneously Hypertensive Rats (SHR) and five Wister Kyoto (WKY) rats were used as the control group. Results showed that retinal arterial diameter and pulse amplitude are significantly lower in the SHRs compared with WKYs. Dynamic biomarkers of retinal micro-vasculature may be used as a diagnostic tool for systemic diseases.
Original language | English |
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Title of host publication | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
Editors | J Patton, R Barbieri, J Ji, E Jabbari, S Dokos, R Mukkamala, D Guiraud, E Jovanov, Y Dhaher, D Panescu, M Vangils, B Wheeler, AP Dhawan |
Place of Publication | New York |
Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
Pages | 3243-3246 |
Number of pages | 4 |
ISBN (Electronic) | 9781457702204 |
DOIs | |
Publication status | Published - 13 Oct 2016 |
Event | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: 16 Aug 2016 → 20 Aug 2016 |
Other
Other | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
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Country/Territory | United States |
City | Orlando |
Period | 16/08/16 → 20/08/16 |