High speed in-vivo imaging of retinal hemodynamics in a rodent model of hypertension

Mahdieh Rezaeian, Dana Georgevsky, S. Mojtaba Golzan, Stuart L. Graham

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

3 Citations (Scopus)

Abstract

The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension. A Eulerian video magnification algorithm was used to extract retinal arterial and venous pulse amplitude from five Spontaneously Hypertensive Rats (SHR) and five Wister Kyoto (WKY) rats were used as the control group. Results showed that retinal arterial diameter and pulse amplitude are significantly lower in the SHRs compared with WKYs. Dynamic biomarkers of retinal micro-vasculature may be used as a diagnostic tool for systemic diseases.

Original languageEnglish
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
EditorsJ Patton, R Barbieri, J Ji, E Jabbari, S Dokos, R Mukkamala, D Guiraud, E Jovanov, Y Dhaher, D Panescu, M Vangils, B Wheeler, AP Dhawan
Place of PublicationNew York
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages3243-3246
Number of pages4
ISBN (Electronic)9781457702204
DOIs
Publication statusPublished - 13 Oct 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
Duration: 16 Aug 201620 Aug 2016

Other

Other38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
CountryUnited States
CityOrlando
Period16/08/1620/08/16

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