Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers.: Results from the DIAN study

Ying Xu; Htein Linn Aung; Randall J. Bateman; William S. Brooks; Jasmeer Chhatwal; Gregory S. Day; Anne M. Fagan; Martin R. Farlow; Brian Gordon; Patrick G. Kehoe; Johannes Levin; Hiroshi Mori; John C. Morris; Whitney Wharton; Peter Humburg; Peter R. Schofield; Ruth Peters; Dominantly Inherited Alzheimer Network (DIAN)

doi:10.1002/alz.13082

Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study

Ying Xu, Htein Linn Aung, Randall J. Bateman, William S. Brooks, Jasmeer Chhatwal, Gregory S. Day, Anne M. Fagan, Martin R. Farlow, Brian Gordon, Patrick G. Kehoe, Johannes Levin, Hiroshi Mori, John C. Morris, Whitney Wharton, Peter Humburg, Peter R. Schofield, Ruth Peters^*, Dominantly Inherited Alzheimer Network (DIAN)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC. RESULTS: Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = −0.181 [−0.318, −0.044]), episodic memory (−0.212 [−0.375, −0.049]), and a composite cognitive measure (−0.146 [−0.276, −0.015]). In NCs, the relationship was cross-sectional only and present for language alone. DISCUSSION: Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.

Original language	English
Pages (from-to)	4999-5009
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	19
Issue number	11
Early online date	23 Apr 2023
DOIs	https://doi.org/10.1002/alz.13082
Publication status	Published - Nov 2023
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

autosomal-dominant Alzheimer's disease
blood pressure
cognition

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Xu, Y., Aung, H. L., Bateman, R. J., Brooks, W. S., Chhatwal, J., Day, G. S., Fagan, A. M., Farlow, M. R., Gordon, B., Kehoe, P. G., Levin, J., Mori, H., Morris, J. C., Wharton, W., Humburg, P., Schofield, P. R., Peters, R., & Dominantly Inherited Alzheimer Network (DIAN) (2023). Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study. Alzheimer's and Dementia, 19(11), 4999-5009. https://doi.org/10.1002/alz.13082

@article{a56bf8e3041041728d750b35a7cf076b,

title = "Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers.: Results from the DIAN study",

abstract = "BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC. RESULTS: Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = −0.181 [−0.318, −0.044]), episodic memory (−0.212 [−0.375, −0.049]), and a composite cognitive measure (−0.146 [−0.276, −0.015]). In NCs, the relationship was cross-sectional only and present for language alone. DISCUSSION: Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.",

keywords = "autosomal-dominant Alzheimer's disease, blood pressure, cognition",

author = "Ying Xu and Aung, {Htein Linn} and Bateman, {Randall J.} and Brooks, {William S.} and Jasmeer Chhatwal and Day, {Gregory S.} and Fagan, {Anne M.} and Farlow, {Martin R.} and Brian Gordon and Kehoe, {Patrick G.} and Johannes Levin and Hiroshi Mori and Morris, {John C.} and Whitney Wharton and Peter Humburg and Schofield, {Peter R.} and Ruth Peters and {Dominantly Inherited Alzheimer Network (DIAN)}",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = nov,

doi = "10.1002/alz.13082",

language = "English",

volume = "19",

pages = "4999--5009",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Wiley-Blackwell, Wiley",

number = "11",

}

Xu, Y, Aung, HL, Bateman, RJ, Brooks, WS, Chhatwal, J, Day, GS, Fagan, AM, Farlow, MR, Gordon, B, Kehoe, PG, Levin, J, Mori, H, Morris, JC, Wharton, W, Humburg, P, Schofield, PR, Peters, R & Dominantly Inherited Alzheimer Network (DIAN) 2023, 'Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study', Alzheimer's and Dementia, vol. 19, no. 11, pp. 4999-5009. https://doi.org/10.1002/alz.13082

Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study. / Xu, Ying; Aung, Htein Linn; Bateman, Randall J. et al.
In: Alzheimer's and Dementia, Vol. 19, No. 11, 11.2023, p. 4999-5009.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers.

T2 - Results from the DIAN study

AU - Xu, Ying

AU - Aung, Htein Linn

AU - Bateman, Randall J.

AU - Brooks, William S.

AU - Chhatwal, Jasmeer

AU - Day, Gregory S.

AU - Fagan, Anne M.

AU - Farlow, Martin R.

AU - Gordon, Brian

AU - Kehoe, Patrick G.

AU - Levin, Johannes

AU - Mori, Hiroshi

AU - Morris, John C.

AU - Wharton, Whitney

AU - Humburg, Peter

AU - Schofield, Peter R.

AU - Peters, Ruth

AU - Dominantly Inherited Alzheimer Network (DIAN)

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC. RESULTS: Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = −0.181 [−0.318, −0.044]), episodic memory (−0.212 [−0.375, −0.049]), and a composite cognitive measure (−0.146 [−0.276, −0.015]). In NCs, the relationship was cross-sectional only and present for language alone. DISCUSSION: Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.

AB - BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC. RESULTS: Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = −0.181 [−0.318, −0.044]), episodic memory (−0.212 [−0.375, −0.049]), and a composite cognitive measure (−0.146 [−0.276, −0.015]). In NCs, the relationship was cross-sectional only and present for language alone. DISCUSSION: Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.

KW - autosomal-dominant Alzheimer's disease

KW - blood pressure

KW - cognition

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DO - 10.1002/alz.13082

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SN - 1552-5260

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JO - Alzheimer's and Dementia

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ER -

Xu Y, Aung HL, Bateman RJ, Brooks WS, Chhatwal J, Day GS et al. Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study. Alzheimer's and Dementia. 2023 Nov;19(11):4999-5009. Epub 2023 Apr 23. doi: 10.1002/alz.13082