Highly efficient Rh(i) and Ir(i) single and dual metal catalysed dihydroalkoxylation reactions of alkyne diols

Joanne Hui Hui Ho, Richard Hodgson, Jörg Wagler, Barbara Ann Messerle

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

A highly efficient rhodium(i) and iridium(i) catalysed dihydroalkoxylation reaction of alkyne diols is employed here for the synthesis of spiroketals and a fused bicyclic ketal. The two metal catalysts show differential selectivity and efficiency for either the cyclisation of the 5-exo or 6-endo-membered rings. For the first time, a dual metal (Rh and Ir) catalyst system is effectively utilised for the formation of the 5,6-spiroketals, more efficiently than the single metal catalysts. The two different metals create a dual activation pathway to enhance the 5- and 6-membered ring closure as compared with the equivalent single catalysts.

Original languageEnglish
Pages (from-to)4062-4069
Number of pages8
JournalDalton Transactions
Volume39
Issue number17
DOIs
Publication statusPublished - 2010
Externally publishedYes

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