Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

Lauren M Hutchins; L Hunter; N Ehya; MD Gibbs; Peter Bergquist; Craig A. Hutton

doi:10.1016/j.tetasy.2004.07.041

Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

Lauren M Hutchins, L Hunter, N Ehya, MD Gibbs, Peter Bergquist, Craig A. Hutton

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Thermoalkalophilic lipases from Geobacillus and Bacillus strains have been cloned and characterised, several of which show excellent activity and enantioselectivity towards various substrates. The hydrolysis of methyl 2-methyldecanoate proceeds to give (R)-2-methyldecanoic acid in good yield and >99% enantiomeric excess (E >200). Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2975-2980
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	15
Issue number	18
DOIs	https://doi.org/10.1016/j.tetasy.2004.07.041
Publication status	Published - 20 Sept 2004

Keywords

BIOCATALYSTS
PCR

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10.1016/j.tetasy.2004.07.041

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title = "Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp",

abstract = "Thermoalkalophilic lipases from Geobacillus and Bacillus strains have been cloned and characterised, several of which show excellent activity and enantioselectivity towards various substrates. The hydrolysis of methyl 2-methyldecanoate proceeds to give (R)-2-methyldecanoic acid in good yield and >99% enantiomeric excess (E >200). Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.",

keywords = "BIOCATALYSTS, PCR",

author = "Hutchins, {Lauren M} and L Hunter and N Ehya and MD Gibbs and Peter Bergquist and Hutton, {Craig A.}",

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language = "English",

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T1 - Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

AU - Hutchins, Lauren M

AU - Hunter, L

AU - Ehya, N

AU - Gibbs, MD

AU - Bergquist, Peter

AU - Hutton, Craig A.

PY - 2004/9/20

Y1 - 2004/9/20

N2 - Thermoalkalophilic lipases from Geobacillus and Bacillus strains have been cloned and characterised, several of which show excellent activity and enantioselectivity towards various substrates. The hydrolysis of methyl 2-methyldecanoate proceeds to give (R)-2-methyldecanoic acid in good yield and >99% enantiomeric excess (E >200). Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

AB - Thermoalkalophilic lipases from Geobacillus and Bacillus strains have been cloned and characterised, several of which show excellent activity and enantioselectivity towards various substrates. The hydrolysis of methyl 2-methyldecanoate proceeds to give (R)-2-methyldecanoic acid in good yield and >99% enantiomeric excess (E >200). Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

KW - BIOCATALYSTS

KW - PCR

U2 - 10.1016/j.tetasy.2004.07.041

DO - 10.1016/j.tetasy.2004.07.041

M3 - Article

SN - 0957-4166

VL - 15

SP - 2975

EP - 2980

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 18

ER -

Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

Abstract

Keywords

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