Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet

Richard J. Stevenson*, Heather M. Francis, Tuki Attuquayefio, Dolly Gupta, Martin R. Yeomans, Megan J. Oaten, Terry Davidson

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)
18 Downloads (Pure)

Abstract

Animals fed a Western-style diet (WS-diet) demonstrate rapid impairments in hippocampal function and poorer appetitive control. We examined if this also occurs in humans. One-hundred and ten healthy lean adults were randomized to either a one-week WS-diet intervention or a habitual-diet control group. Measures of hippocampal-dependent learning and memory (HDLM) and of appetitive control were obtained pre- and post-intervention. HDLM was retested at three-week follow-up. Relative to controls, HDLM performance declined in the WS-diet group (d = 0.43), but was not different at followup. Appetitive control also declined in the WS-diet group (d = 0.47) and this was strongly correlated with HDLM decline (d = 1.01). These findings demonstrate that a WS-diet can rapidly impair appetitive control in humans-an effect that could promote overeating in consumers of a WS-diet. The study also suggests a functional role for the hippocampus in appetitive control and provides new evidence for the adverse neurocognitive effects of a WS-diet.

Original languageEnglish
Article number191338
Pages (from-to)1-14
Number of pages14
JournalRoyal Society Open Science
Volume7
Issue number2
DOIs
Publication statusPublished - 19 Feb 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • inhibition
  • appetite
  • ingestive behaviour
  • Western-style diet

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