Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects

C. E. Shepherd; O. Piguet; G. A. Broe; H. Creasey; L. M. Waite; W. S. Brooks; J. J. Kril

doi:10.1016/j.jneuroim.2003.11.007

Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects

C. E. Shepherd^*, O. Piguet, G. A. Broe, H. Creasey, L. M. Waite, W. S. Brooks, J. J. Kril

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

HLA genotype and anti-inflammatory drug use have independently been associated with a lower risk of Alzheimer's disease (AD). We recently reported a negative association between aspirin use and AD. To investigate this further, we performed a cross-sectional study to investigate cognitive performance in 151 non-demented individuals in relation to HLA-DRB1 genotype and aspirin use. Aspirin and HLA-DRB1*01 were positive predictors of performance on logical memory (aspirin, p=0.04) and verbal fluency tests (HLA-DRB1*01, p=0.018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects.

Original language	English
Pages (from-to)	178-182
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	148
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.11.007
Publication status	Published - Mar 2004
Externally published	Yes

Keywords

Anti-inflammatory
Cognition
Human leukocyte antigen

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10.1016/j.jneuroim.2003.11.007

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title = "Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects",

abstract = "HLA genotype and anti-inflammatory drug use have independently been associated with a lower risk of Alzheimer's disease (AD). We recently reported a negative association between aspirin use and AD. To investigate this further, we performed a cross-sectional study to investigate cognitive performance in 151 non-demented individuals in relation to HLA-DRB1 genotype and aspirin use. Aspirin and HLA-DRB1*01 were positive predictors of performance on logical memory (aspirin, p=0.04) and verbal fluency tests (HLA-DRB1*01, p=0.018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects.",

keywords = "Anti-inflammatory, Cognition, Human leukocyte antigen",

author = "Shepherd, {C. E.} and O. Piguet and Broe, {G. A.} and H. Creasey and Waite, {L. M.} and Brooks, {W. S.} and Kril, {J. J.}",

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TY - JOUR

T1 - Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects

AU - Shepherd, C. E.

AU - Piguet, O.

AU - Broe, G. A.

AU - Creasey, H.

AU - Waite, L. M.

AU - Brooks, W. S.

AU - Kril, J. J.

PY - 2004/3

Y1 - 2004/3

N2 - HLA genotype and anti-inflammatory drug use have independently been associated with a lower risk of Alzheimer's disease (AD). We recently reported a negative association between aspirin use and AD. To investigate this further, we performed a cross-sectional study to investigate cognitive performance in 151 non-demented individuals in relation to HLA-DRB1 genotype and aspirin use. Aspirin and HLA-DRB1*01 were positive predictors of performance on logical memory (aspirin, p=0.04) and verbal fluency tests (HLA-DRB1*01, p=0.018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects.

AB - HLA genotype and anti-inflammatory drug use have independently been associated with a lower risk of Alzheimer's disease (AD). We recently reported a negative association between aspirin use and AD. To investigate this further, we performed a cross-sectional study to investigate cognitive performance in 151 non-demented individuals in relation to HLA-DRB1 genotype and aspirin use. Aspirin and HLA-DRB1*01 were positive predictors of performance on logical memory (aspirin, p=0.04) and verbal fluency tests (HLA-DRB1*01, p=0.018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects.

KW - Anti-inflammatory

KW - Cognition

KW - Human leukocyte antigen

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DO - 10.1016/j.jneuroim.2003.11.007

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ER -

Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects

Abstract

Keywords

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