Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects

C. E. Shepherd*, O. Piguet, G. A. Broe, H. Creasey, L. M. Waite, W. S. Brooks, J. J. Kril

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


HLA genotype and anti-inflammatory drug use have independently been associated with a lower risk of Alzheimer's disease (AD). We recently reported a negative association between aspirin use and AD. To investigate this further, we performed a cross-sectional study to investigate cognitive performance in 151 non-demented individuals in relation to HLA-DRB1 genotype and aspirin use. Aspirin and HLA-DRB1*01 were positive predictors of performance on logical memory (aspirin, p=0.04) and verbal fluency tests (HLA-DRB1*01, p=0.018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Mar 2004
Externally publishedYes


  • Anti-inflammatory
  • Cognition
  • Human leukocyte antigen


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