HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

Albert M. Anderson; David Croteau; Ronald J. Ellis; Debra Rosario; Michael Potter; Gilles J. Guillemin; Bruce J. Brew; Steven Paul Woods; Scott L. Letendre

doi:10.1016/j.jneuroim.2018.03.007

HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

Albert M. Anderson^*, David Croteau, Ronald J. Ellis, Debra Rosario, Michael Potter, Gilles J. Guillemin, Bruce J. Brew, Steven Paul Woods, Scott L. Letendre

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.

Original language	English
Pages (from-to)	13-18
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	319
DOIs	https://doi.org/10.1016/j.jneuroim.2018.03.007
Publication status	Published - 15 Jun 2018

Keywords

Acquired immunodeficiency syndrome
Cerebrospinal fluid
Human immunodeficiency virus
Neurocognitive disorder
Tau proteins
Tryptophan

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10.1016/j.jneuroim.2018.03.007

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title = "HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau",

abstract = "There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.",

keywords = "Acquired immunodeficiency syndrome, Cerebrospinal fluid, Human immunodeficiency virus, Neurocognitive disorder, Tau proteins, Tryptophan",

author = "Anderson, {Albert M.} and David Croteau and Ellis, {Ronald J.} and Debra Rosario and Michael Potter and Guillemin, {Gilles J.} and Brew, {Bruce J.} and Woods, {Steven Paul} and Letendre, {Scott L.}",

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T1 - HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

AU - Anderson, Albert M.

AU - Croteau, David

AU - Ellis, Ronald J.

AU - Rosario, Debra

AU - Potter, Michael

AU - Guillemin, Gilles J.

AU - Brew, Bruce J.

AU - Woods, Steven Paul

AU - Letendre, Scott L.

PY - 2018/6/15

Y1 - 2018/6/15

N2 - There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.

AB - There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.

KW - Acquired immunodeficiency syndrome

KW - Cerebrospinal fluid

KW - Human immunodeficiency virus

KW - Neurocognitive disorder

KW - Tau proteins

KW - Tryptophan

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DO - 10.1016/j.jneuroim.2018.03.007

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SN - 0165-5728

VL - 319

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

Abstract

Keywords

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