HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

Albert M. Anderson*, David Croteau, Ronald J. Ellis, Debra Rosario, Michael Potter, Gilles J. Guillemin, Bruce J. Brew, Steven Paul Woods, Scott L. Letendre

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.

    Original languageEnglish
    Pages (from-to)13-18
    Number of pages6
    JournalJournal of Neuroimmunology
    Volume319
    DOIs
    Publication statusPublished - 15 Jun 2018

    Keywords

    • Acquired immunodeficiency syndrome
    • Cerebrospinal fluid
    • Human immunodeficiency virus
    • Neurocognitive disorder
    • Tau proteins
    • Tryptophan

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