HLA-DP variation as additional risk factor in IDDM

Simon Easteal; Maija R. J. Kohonen-Corish; Paul Zimmet; Susan W. Serjeantson

doi:10.2337/diab.39.7.855

HLA-DP variation as additional risk factor in IDDM

Simon Easteal^*, Maija R. J. Kohonen-Corish, Paul Zimmet, Susan W. Serjeantson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

Original language	English
Pages (from-to)	855-857
Number of pages	3
Journal	Diabetes
Volume	39
Issue number	7
DOIs	https://doi.org/10.2337/diab.39.7.855
Publication status	Published - 1990
Externally published	Yes

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title = "HLA-DP variation as additional risk factor in IDDM",

abstract = "A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.",

author = "Simon Easteal and Kohonen-Corish, {Maija R. J.} and Paul Zimmet and Serjeantson, {Susan W.}",

year = "1990",

doi = "10.2337/diab.39.7.855",

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T1 - HLA-DP variation as additional risk factor in IDDM

AU - Easteal, Simon

AU - Kohonen-Corish, Maija R. J.

AU - Zimmet, Paul

AU - Serjeantson, Susan W.

PY - 1990

Y1 - 1990

N2 - A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

AB - A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

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DO - 10.2337/diab.39.7.855

M3 - Article

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AN - SCOPUS:0025316540

SN - 0012-1797

VL - 39

SP - 855

EP - 857

JO - Diabetes

JF - Diabetes

IS - 7

ER -

HLA-DP variation as additional risk factor in IDDM

Abstract

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