HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.

S. W. Serjeantson; P. R. Ranford; R. L. Kirk; M. R. Kohonen-Corish; V. Mohan; A. Ramachandran; C. Snehalatha; M. Viswanathan

HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.

S. W. Serjeantson^*, P. R. Ranford, R. L. Kirk, M. R. Kohonen-Corish, V. Mohan, A. Ramachandran, C. Snehalatha, M. Viswanathan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Restriction fragment length polymorphisms (RFLPs) of the HLA-DR beta, -DQ alpha, -DQ beta, and -DX alpha genes have been examined in South Indian diabetic patients and controls. The DR. DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ beta allele in the pathogenesis of IDDM.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Disease Markers
Volume	5
Issue number	2
Publication status	Published - Jun 1987
Externally published	Yes

Cite this

@article{648ada2eeace4ee9a20fb144f050aade,

title = "HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.",

abstract = "Restriction fragment length polymorphisms (RFLPs) of the HLA-DR beta, -DQ alpha, -DQ beta, and -DX alpha genes have been examined in South Indian diabetic patients and controls. The DR. DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ beta allele in the pathogenesis of IDDM.",

author = "Serjeantson, {S. W.} and Ranford, {P. R.} and Kirk, {R. L.} and Kohonen-Corish, {M. R.} and V. Mohan and A. Ramachandran and C. Snehalatha and M. Viswanathan",

year = "1987",

month = jun,

language = "English",

volume = "5",

pages = "101--108",

journal = "Disease Markers",

issn = "0278-0240",

publisher = "Hindawi Limited",

number = "2",

}

TY - JOUR

T1 - HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.

AU - Serjeantson, S. W.

AU - Ranford, P. R.

AU - Kirk, R. L.

AU - Kohonen-Corish, M. R.

AU - Mohan, V.

AU - Ramachandran, A.

AU - Snehalatha, C.

AU - Viswanathan, M.

PY - 1987/6

Y1 - 1987/6

N2 - Restriction fragment length polymorphisms (RFLPs) of the HLA-DR beta, -DQ alpha, -DQ beta, and -DX alpha genes have been examined in South Indian diabetic patients and controls. The DR. DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ beta allele in the pathogenesis of IDDM.

AB - Restriction fragment length polymorphisms (RFLPs) of the HLA-DR beta, -DQ alpha, -DQ beta, and -DX alpha genes have been examined in South Indian diabetic patients and controls. The DR. DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ beta allele in the pathogenesis of IDDM.

UR - http://www.scopus.com/inward/record.url?scp=0023357003&partnerID=8YFLogxK

M3 - Article

C2 - 2901931

AN - SCOPUS:0023357003

SN - 0278-0240

VL - 5

SP - 101

EP - 108

JO - Disease Markers

JF - Disease Markers

IS - 2

ER -

HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.

Abstract

Other files and links

Fingerprint

Cite this