Homocysteine and retinal vein occlusion: A Population-based study

Brian Chua, Annette Kifley, Tien Y. Wong, Paul Mitchell

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


To report population data on the association between homocysteinemia and retinal vein occlusion (RVO). Cross-sectional, population-based study. Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years). Its association with RVO (graded from retinal photographs) was examined. Homocysteine was more strongly associated with RVO in younger than older participants. In those aged <70 years, homocysteine levels >15 μmol/l were associated with increased odds of RVO, odds ratio (OR) 3.76; 95% confidence interval (CI) 1.06-13.40, in multivariable-adjusted analyses. Each 1 μmol/l increase in homocysteine was associated with a 7% increased odds of RVO, OR 1.07; CI 0.99-1.17 (P =. 08). This population-based study showed that elevated serum homocysteine is associated with the presence of RVO, independent of other risk factors.

Original languageEnglish
Pages (from-to)181-182
Number of pages2
JournalAmerican Journal of Ophthalmology
Issue number1
Publication statusPublished - Jan 2005
Externally publishedYes


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