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Antibiotics used in combination are an effective strategy for combatting numerous infectious diseases in clinical and veterinary settings, particularly as a last-line therapy for difficult-to-treat cases. Combination therapy can either increase or slow the rate of killing, broaden the antibiotic spectrum, reduce dosage and unwanted side-effects, and even control the emergence of resistance. The administration of antibiotics in combination has been used effectively against bacterial infections for >70 years, first used to treat tuberculosis. However, effective antibiotic combinations and their dosage regimes have been largely determined empirically in the clinic, and the molecular mechanisms underpinning how these combinations work remains surprisingly elusive. This review focuses on studies that have outlined the genetics and molecular mechanisms of action underlying antibiotic combinations, as well as those that examine how resistance develops. We highlight the need for further experimentation and genetic validation to fully realise the potential of combination therapy.
|Number of pages||10|
|Journal||Current Opinion in Microbiology|
|Early online date||30 Jun 2020|
|Publication status||Published - Oct 2020|
Bibliographical noteCopyright © 2020 Elsevier Ltd. All rights reserved. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
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A molecular balancing act: understanding metal ion homeostasis in A. baumannii during infection
Eijkelkamp, B. & Cain, A.
1/01/19 → 12/12/23
Stronger Together: Understanding Antibiotic Synergy on a Molecular Level
3/12/18 → 3/12/21