How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations

Andrew S. Davidson, Michael K. Morgan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: Existing studies reporting the risk of surgery for brain arteriovenous malformations (AVMs) are often biased by the exclusion of patients not offered surgery. In this study, we examine the risk of surgery, including cases excluded from surgery because of the high surgical risk. Methods: Data were collected on 640 consecutively enrolled AVMs in a database that included all patients not considered for surgery. Results: Patients with Spetzler-Martin grade 1 to 2 AVMs (n = 296) were treated with a surgical risk of 0.7% (95% confidence interval [CI], 0%-3%); patients with Spetzler-Martin grade 3 to 4 AVMs in noneloquent cortex (n = 65) were treated with a surgical risk of 17% (95% CI, 10%-28%). Patients with Spetzler-Martin grade 3 to 5 AVMs in eloquent cortex (n = 168) were treated with a surgical risk of 21% (95% CI, 15%-28%). However, because 14% of patients in this series with similar AVMs were refused surgery because of perceived surgical risk, these results are not generalizable to the population of patients with similar AVMs. Conclusion: The results of this series suggest that it is reasonable to offer surgery as a preferred treatment option for Spetzler-Martin grade 1 to 2 AVMs. This study also reinforces the predictive value of the Spetzler-Martin grading system, with some caveats.

LanguageEnglish
Pages498-504
Number of pages7
JournalNeurosurgery
Volume66
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Arteriovenous Malformations
Observational Studies
Prospective Studies
Brain
Confidence Intervals
Therapeutics
Databases
Population

Cite this

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title = "How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations",
abstract = "Objectives: Existing studies reporting the risk of surgery for brain arteriovenous malformations (AVMs) are often biased by the exclusion of patients not offered surgery. In this study, we examine the risk of surgery, including cases excluded from surgery because of the high surgical risk. Methods: Data were collected on 640 consecutively enrolled AVMs in a database that included all patients not considered for surgery. Results: Patients with Spetzler-Martin grade 1 to 2 AVMs (n = 296) were treated with a surgical risk of 0.7{\%} (95{\%} confidence interval [CI], 0{\%}-3{\%}); patients with Spetzler-Martin grade 3 to 4 AVMs in noneloquent cortex (n = 65) were treated with a surgical risk of 17{\%} (95{\%} CI, 10{\%}-28{\%}). Patients with Spetzler-Martin grade 3 to 5 AVMs in eloquent cortex (n = 168) were treated with a surgical risk of 21{\%} (95{\%} CI, 15{\%}-28{\%}). However, because 14{\%} of patients in this series with similar AVMs were refused surgery because of perceived surgical risk, these results are not generalizable to the population of patients with similar AVMs. Conclusion: The results of this series suggest that it is reasonable to offer surgery as a preferred treatment option for Spetzler-Martin grade 1 to 2 AVMs. This study also reinforces the predictive value of the Spetzler-Martin grading system, with some caveats.",
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How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations. / Davidson, Andrew S.; Morgan, Michael K.

In: Neurosurgery, Vol. 66, No. 3, 03.2010, p. 498-504.

Research output: Contribution to journalArticleResearchpeer-review

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