How to interrogate the cellular immune system in patients with ischemic heart disease

Alana N. Mohamed*, Sean Lal, Joshua W.K. Ho, Angus Brown, Rodney Lui, Lisa Nguyen, Andy S.C. Yong, Yingying Su, Filip Braet, Wayne Dyer, Frank Junius, Robert G. Cumming, S. Benedict Freedman, Leonard Kritharides, Cristobal G. Dos Remedios

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Coronary artery disease (CAD) is caused by atherosclerosis, a disease of the large arteries. Blockage of the coronary circulation can result in ischaemia and eventual myocardial infarction. Patients with CAD may be classified into two groups: stable CAD where patients are asymptomatic or have stable effort angina, and unstable CAD manifesting as acute coronary syndrome. The latter is further divided into patients with unstable angina and patients with myocardial infarction (MI). Stable angina is characterised by a relatively stable stenosis in one or more coronary arteries. Unstable CAD is characterised by an unstable atherosclerotic plaque with either rupture or erosion of the fibrous cap exposing the pro-thrombogenic core. This may lead to downstream vessel occlusion. The challenge is to identify those individuals who will progress from stable to unstable disease. This is likely to involve an ongoing inflammatory response, which is the basis for the disease. Leukocytes play a key role in this process. We conclude that the state of coronary artery disease-associated inflammation can be monitored by: (1) quantifying the expression of protein markers (cluster of differentiation or CD antigens) on the surface of peripheral blood mononuclear cells isolated from both stable and unstable angina patients; and (2) qualitative analysis of cellular fragments (microparticles) released into the plasma as a result of inflammation-induced apoptosis.

Original languageEnglish
Title of host publicationMyocardial ischemia
Subtitle of host publicationcauses, symptoms and treatment
EditorsD Vukovic, Kiyan
Place of PublicationHauppauge, NY
PublisherNova Science Publishers
Pages195-216
Number of pages22
ISBN (Electronic)9781613244364
ISBN (Print)9781608766109
Publication statusPublished - 1 Jan 2010

Publication series

NameCardiology Research and Clinical Developments
PublisherNOVA SCIENCE PUBLISHERS, INC

Keywords

  • Acute coronary syndrome
  • Antibody microarrays
  • Classification of coronary artery disease
  • Cluster of differentiation antigens
  • Coronary artery disease
  • Diagnosing coronary artery disease
  • Leukocytes and coronary artery disease
  • Limitations with current diagnostic methods
  • Microparticles
  • Microparticles and coronary artery disease
  • Myocardial infarction
  • Pathophysiology of coronary artery disease
  • Scanning electron microscopy
  • Stable angina
  • Unstable angina

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