Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

Yun-An Lim, Lars M. Ittner, Yun Li Lim, Jürgen Götz*

*Corresponding author for this work

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.

Original languageEnglish
Pages (from-to)2188-2194
Number of pages7
JournalFEBS Letters
Volume582
Issue number15
DOIs
Publication statusPublished - 25 Jun 2008
Externally publishedYes

Keywords

  • Aβ42 amyloid
  • Alzheimer's disease
  • Amylin
  • Cell-type specificity
  • Conformational disease
  • IAPP
  • Neurotoxicity
  • Type 2 diabetes mellitus

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