Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

Yun-An Lim; Lars M. Ittner; Yun Li Lim; Jürgen Götz

doi:10.1016/j.febslet.2008.05.006

Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

Yun-An Lim, Lars M. Ittner, Yun Li Lim, Jürgen Götz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.

Original language	English
Pages (from-to)	2188-2194
Number of pages	7
Journal	FEBS Letters
Volume	582
Issue number	15
DOIs	https://doi.org/10.1016/j.febslet.2008.05.006
Publication status	Published - 25 Jun 2008
Externally published	Yes

Keywords

Aβ42 amyloid
Alzheimer's disease
Amylin
Cell-type specificity
Conformational disease
IAPP
Neurotoxicity
Type 2 diabetes mellitus

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10.1016/j.febslet.2008.05.006

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title = "Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures",

abstract = "Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.",

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AU - Lim, Yun-An

AU - Ittner, Lars M.

AU - Lim, Yun Li

AU - Götz, Jürgen

PY - 2008/6/25

Y1 - 2008/6/25

N2 - Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.

AB - Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.

KW - Aβ42 amyloid

KW - Alzheimer's disease

KW - Amylin

KW - Cell-type specificity

KW - Conformational disease

KW - IAPP

KW - Neurotoxicity

KW - Type 2 diabetes mellitus

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Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

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Keywords

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