Human disease glycomics: technology advances enabling protein glycosylation analysis – part 2

Arun V. Everest-Dass, Edward S. X. Moh, Christopher Ashwood, Abdulrahman M. M. Shathili, Nicolle H. Packer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases.

Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described.

Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalExpert Review of Proteomics
Issue number4
Publication statusPublished - 2018


  • Glycomics
  • glycan structure
  • glycan analysis
  • mass spectrometry
  • disease glycomics


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