TY - JOUR
T1 - Human disease glycomics
T2 - technology advances enabling protein glycosylation analysis – part 2
AU - Everest-Dass, Arun V.
AU - Moh, Edward S. X.
AU - Ashwood, Christopher
AU - Shathili, Abdulrahman
AU - Packer, Nicolle H.
PY - 2018
Y1 - 2018
N2 - Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases. Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described. Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.
AB - Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases. Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described. Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.
KW - Glycomics
KW - glycan structure
KW - glycan analysis
KW - mass spectrometry
KW - disease glycomics
UR - http://www.scopus.com/inward/record.url?scp=85045840867&partnerID=8YFLogxK
U2 - 10.1080/14789450.2018.1448710
DO - 10.1080/14789450.2018.1448710
M3 - Review article
C2 - 29521143
AN - SCOPUS:85045840867
SN - 1478-9450
VL - 15
SP - 341
EP - 352
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
IS - 4
ER -