Human disease glycomics: technology advances enabling protein glycosylation analysis – part 2

Arun V. Everest-Dass, Edward S. X. Moh, Christopher Ashwood, Abdulrahman M. M. Shathili, Nicolle H. Packer

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases.

Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described.

Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.

LanguageEnglish
Pages341-352
Number of pages12
JournalExpert Review of Proteomics
Volume15
Issue number4
DOIs
Publication statusPublished - 2018

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Glycomics
Glycosylation
Polysaccharides
Technology
Proteins
Metabolomics
Disease Management
Genomics
Epigenomics
Proteomics
Medical problems
Inflammation
Antibodies
Neoplasms

Cite this

Everest-Dass, Arun V. ; Moh, Edward S. X. ; Ashwood, Christopher ; Shathili, Abdulrahman M. M. ; Packer, Nicolle H. / Human disease glycomics : technology advances enabling protein glycosylation analysis – part 2. In: Expert Review of Proteomics. 2018 ; Vol. 15, No. 4. pp. 341-352.
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Human disease glycomics : technology advances enabling protein glycosylation analysis – part 2. / Everest-Dass, Arun V.; Moh, Edward S. X.; Ashwood, Christopher; Shathili, Abdulrahman M. M.; Packer, Nicolle H.

In: Expert Review of Proteomics, Vol. 15, No. 4, 2018, p. 341-352.

Research output: Contribution to journalReview articleResearchpeer-review

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